174883

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2704256..2704767 Replicon chromosome
Accession NZ_CP062400
Organism Staphylococcus aureus strain NAS_OP_107

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag IF772_RS13410 Protein ID WP_001103943.1
Coordinates 2704468..2704767 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag IF772_RS13405 Protein ID WP_001058486.1
Coordinates 2704256..2704465 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF772_RS13370 (2699555) 2699555..2699839 + 285 WP_000917289.1 co-chaperone GroES -
IF772_RS13375 (2699915) 2699915..2701531 + 1617 WP_000240645.1 chaperonin GroEL -
IF772_RS13380 (2701600) 2701600..2702772 - 1173 WP_000179352.1 tyrosine-type recombinase/integrase -
IF772_RS13385 (2702781) 2702781..2703413 - 633 WP_000616253.1 helix-turn-helix transcriptional regulator -
IF772_RS13390 (2703587) 2703587..2703799 + 213 WP_000794315.1 helix-turn-helix transcriptional regulator -
IF772_RS13395 (2703803) 2703803..2704120 + 318 WP_000459698.1 helix-turn-helix domain-containing protein -
IF772_RS13400 (2704117) 2704117..2704263 + 147 WP_000784875.1 hypothetical protein -
IF772_RS13405 (2704256) 2704256..2704465 + 210 WP_001058486.1 hypothetical protein Antitoxin
IF772_RS13410 (2704468) 2704468..2704767 + 300 WP_001103943.1 DUF1474 family protein Toxin
IF772_RS13415 (2704842) 2704842..2706458 + 1617 WP_000344761.1 hypothetical protein -
IF772_RS13420 (2706634) 2706634..2707437 + 804 WP_000148374.1 bifunctional DNA primase/polymerase -
IF772_RS13425 (2707424) 2707424..2707696 + 273 WP_001149387.1 hypothetical protein -
IF772_RS13430 (2707698) 2707698..2708339 + 642 WP_001019765.1 hypothetical protein -
IF772_RS13435 (2708686) 2708686..2709027 + 342 WP_001161659.1 hypothetical protein -
IF772_RS13440 (2709039) 2709039..2709617 + 579 WP_000846292.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb 2696568..2744742 48174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11795.24 Da        Isoelectric Point: 4.5689

>T174883 WP_001103943.1 NZ_CP062400:2704468-2704767 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDA

Download         Length: 300 bp

>T174883 NZ_CP081701:870346-871659 [Escherichia coli]
ATGAAAATGCAGACGCTAACAGTGGCGATGAATGGTGAGGTCGTAGGAACACTGTACCGAGATAACAAAGGGGCCATGTC
ATTTCAGTATGCCCCGGAGTGGATCTCGGAACCAGGTTCACGCGCCATTTCCATGTCACTGCCTTTGGGTCATGGCAGGA
TCACAGGAAGTGAAGTCTTCAATTTCTTTAGCAACCTCCTACCCGACTCAGAGGCAATTATTGCCAGGATGCAGGCTAGG
TTCAGAGTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGATTGTGTTGGAGCTATCCAGCTCTATTC
CCCCGATGCGGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGAAGCTCAGATTGAGCAACTGCTTGAAG
GCTACCAGGAAGCGCCCCTTGGGATGGCAGAGGATGCTGATTTTCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCA
CTGCTTTGGTATCAGGACCGCTGGCAACGCCCCCTGGGCAGCACCCCAACAAGCCATATTTTTAAGCTACCCATTGGTAA
GATTGTTCAAAATAACATCGATCTCAGTGAGAGTTGTGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGTT
TTGACGTCGCCAATGCGGACCTAGCAACGTTCGGCAAGAAGAAGGTGCTTGTCGTTCAGCGTTTTGACCGGCGCTGGTCT
AAATCCGGCGAATGGCTTCTACGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGGATCGCTCCTGCGCTCAAATACGA
GTCACATGGAGGGCCAGGTATTGCTGACGCAATGAAGTTGTTGTTGGGGTCCAGACTTGCGGCTAAGGATAGAGAGCAAT
TTTTCAAGTCGCAGATCCTATTCTGGATGTTGGCCGCGATTGATGGGCACGGGAAGAACTTCTCCATCTTCATTGAGCCT
GCATCGTCATTTAGGATGACCCCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCTGCTCA
AAAGGCAAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACCATTTTGCGATGATCCAGCCTCGTCATTTTATCA
GTACCGCCGCCCATGTCGGGTTCCCACAAGATACCGCCGCTCAACTTATGTTCGACATGGCTACCAAGACAGAGGAGGTG
GTTGCCACAGTAGCGGCTGAGCTGCCAGCCGGTTTCCCAGAGCACATCAGTAGCGCCATCTTCGAGGGGCTGTCCAGCCA
GGCGGCTAAGATCTTGAAGGGAGTAGCCAAATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT174883 WP_001058486.1 NZ_CP062400:2704256-2704465 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT174883 NZ_CP081701:870091-870342 [Escherichia coli]
ATGAAAGTGACATCTCCATCCTTGCTTGCGGCTGCGGTGCGTGACCAGCGCAAGCTCAGCAAACTAACGCAGTCAGAGGC
GGCGAAACAGGTCGGAATCAAGCAGACGACCGTCTCTGATTTTGAACTACGGCCAGAATCTACCAAGCTGGAGACGCTAT
TCAAGCTCCTTTCTGCACTGGATCTGGAGCTTCATGTCGTGAAGCGGGGTTCAACATTGGACGATAGTAAAGTCTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References