Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2650248..2650777 Replicon chromosome
Accession NZ_CP062400
Organism Staphylococcus aureus strain NAS_OP_107

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF772_RS13125 Protein ID WP_000621175.1
Coordinates 2650415..2650777 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF772_RS13120 Protein ID WP_000948331.1
Coordinates 2650248..2650418 (+) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF772_RS13090 (2645285) 2645285..2645845 + 561 WP_001092409.1 K(+)-transporting ATPase subunit C -
IF772_RS13095 (2646054) 2646054..2646533 + 480 WP_001287079.1 hypothetical protein -
IF772_RS13100 (2646526) 2646526..2648108 + 1583 Protein_2545 PH domain-containing protein -
IF772_RS13105 (2648095) 2648095..2648586 + 492 WP_001205912.1 PH domain-containing protein -
IF772_RS13110 (2648590) 2648590..2648949 + 360 WP_000581197.1 holo-ACP synthase -
IF772_RS13115 (2649015) 2649015..2650163 + 1149 WP_001281154.1 alanine racemase -
IF772_RS13120 (2650248) 2650248..2650418 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF772_RS13125 (2650415) 2650415..2650777 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF772_RS13130 (2651127) 2651127..2652128 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF772_RS13135 (2652247) 2652247..2652573 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF772_RS13140 (2652575) 2652575..2653054 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IF772_RS13145 (2653029) 2653029..2653799 + 771 WP_001041102.1 RNA polymerase sigma factor SigB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174882 WP_000621175.1 NZ_CP062400:2650415-2650777 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174882 NZ_CP081701:836552-836836 [Escherichia coli]
GTGTATAAACTCACTGAACGGGCAGCAGACGACTTCGCCGGGATTTATGACTATACGCTCTTGAAATTTGGTGAAGCTCA
GGCAGACCATTATACAGACGCACTTGAGGCATTTTTCGAGACACTGGCCGGAATGCCAGATATGGGACGTGACTACCATA
CCGTTCCTGGTGTGATGCGCATTGAATTTCAGCGACATGCCATTTTTTATACGGTTCGTGATACGGATATTCTGATTGCG
CGTATTTTGCACCAACAGATGAACCATAAACGCCATTTACTGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174882 WP_000948331.1 NZ_CP062400:2650248-2650418 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174882 NZ_CP081701:836317-836559 [Escherichia coli]
ATGGCCAGAACAACAAGCGTTACGATTGGCGAACAACTCGATTCGTTTATTAGTCGATTAATAGACAGTGGCCGTTACGG
CTCTGCGAGTGAAGTTATGCGTTCTGCGCTGCGATTGCTGGAGCAACAGGAAACAAACGATGAAGTTATTCGTCAGGCTG
TTATTGCTGGGCTGGAAAGCGGTGAAAGCTCGCTATCACTGCGGGATATTGCAGCACAAAGAAAACTGAGACATCGTGTA
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References