Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2630510..2631024 Replicon chromosome
Accession NZ_CP062400
Organism Staphylococcus aureus strain NAS_OP_107

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF772_RS13035 Protein ID WP_000581792.1
Coordinates 2630815..2631024 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF772_RS13030 Protein ID WP_000138932.1
Coordinates 2630510..2630803 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF772_RS13010 (2625981) 2625981..2626622 + 642 WP_000483153.1 thiamine phosphate synthase -
IF772_RS13015 (2626708) 2626708..2627580 + 873 WP_000725802.1 membrane protein insertase YidC -
IF772_RS13020 (2628185) 2628185..2628832 - 648 WP_001187630.1 HD domain-containing protein -
IF772_RS13025 (2628860) 2628860..2630344 - 1485 WP_000571549.1 cardiolipin synthase -
IF772_RS13030 (2630510) 2630510..2630803 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF772_RS13035 (2630815) 2630815..2631024 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF772_RS13040 (2631152) 2631152..2631289 + 138 WP_000828354.1 Lmo0850 family protein -
IF772_RS13045 (2631553) 2631553..2632755 - 1203 WP_001836940.1 FtsW/RodA/SpoVE family cell cycle protein -
IF772_RS13050 (2633073) 2633073..2634143 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF772_RS13055 (2634158) 2634158..2635516 + 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174881 WP_000581792.1 NZ_CP062400:2630815-2631024 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174881 NZ_CP081701:716205-716582 [Escherichia coli]
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174881 WP_000138932.1 NZ_CP062400:2630510-2630803 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174881 NZ_CP081701:715795-716154 [Escherichia coli]
TTGTCGAATGAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTACAGGCGGGCAACCGTCTGCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACG
CTGATTTACGGTATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAAT
CCCTGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References