Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1157303..1157780 Replicon chromosome
Accession NZ_CP062400
Organism Staphylococcus aureus strain NAS_OP_107

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF772_RS05850 Protein ID WP_000052076.1
Coordinates 1157592..1157780 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF772_RS05845 Protein ID WP_001059690.1
Coordinates 1157303..1157563 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF772_RS05810 (1152696) 1152696..1153412 - 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -
IF772_RS05815 (1153560) 1153560..1153982 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF772_RS05820 (1154381) 1154381..1154875 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF772_RS05825 (1155030) 1155030..1155647 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
IF772_RS05830 (1155720) 1155720..1156301 - 582 WP_001140697.1 histidine phosphatase family protein -
IF772_RS05835 (1156526) 1156526..1156762 + 237 WP_000368687.1 hypothetical protein -
IF772_RS05840 (1156759) 1156759..1156962 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF772_RS05845 (1157303) 1157303..1157563 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF772_RS05850 (1157592) 1157592..1157780 + 189 WP_000052076.1 hypothetical protein Toxin
IF772_RS05855 (1157968) 1157968..1158537 + 570 WP_001106653.1 lipoprotein N-acylation protein LnsA -
IF772_RS05860 (1158625) 1158625..1158909 + 285 WP_001004394.1 hypothetical protein -
IF772_RS05865 (1158971) 1158971..1159189 + 219 WP_000005884.1 hypothetical protein -
IF772_RS05870 (1159684) 1159684..1159884 - 201 WP_001059082.1 cold-shock protein -
IF772_RS05875 (1160241) 1160241..1160927 - 687 WP_001548082.1 thermonuclease family protein -
IF772_RS05880 (1161268) 1161268..1161738 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174877 WP_000052076.1 NZ_CP062400:1157592-1157780 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174877 NZ_CP081701:187027-187134 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174877 WP_001059690.1 NZ_CP062400:1157303-1157563 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174877 NZ_CP081701:c186970-186912 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References