Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 120068..120844 Replicon chromosome
Accession NZ_CP062400
Organism Staphylococcus aureus strain NAS_OP_107

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag IF772_RS00765 Protein ID WP_000031108.1
Coordinates 120692..120844 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag IF772_RS00760 Protein ID WP_001251224.1
Coordinates 120068..120667 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF772_RS00740 (115983) 115983..117440 + 1458 WP_000649907.1 ABC transporter permease subunit -
IF772_RS00745 (117433) 117433..118155 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF772_RS00750 (118307) 118307..119434 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
IF772_RS00755 (119439) 119439..119909 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF772_RS00760 (120068) 120068..120667 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
IF772_RS00765 (120692) 120692..120844 + 153 WP_000031108.1 SAS053 family protein Toxin
IF772_RS00770 (121388) 121388..121783 + 396 WP_000901023.1 hypothetical protein -
IF772_RS00775 (121979) 121979..123364 + 1386 WP_000116229.1 class II fumarate hydratase -
IF772_RS00780 (123816) 123816..124637 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T174876 WP_000031108.1 NZ_CP062400:120692-120844 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T174876 NZ_CP081701:186544-186651 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT174876 WP_001251224.1 NZ_CP062400:120068-120667 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT174876 NZ_CP081701:c186486-186429 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References