Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2133315..2133829 Replicon chromosome
Accession NZ_CP062399
Organism Staphylococcus aureus strain NAS_OP_143

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF777_RS10545 Protein ID WP_000581792.1
Coordinates 2133315..2133524 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF777_RS10550 Protein ID WP_000138932.1
Coordinates 2133536..2133829 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF777_RS10525 (IF777_10485) 2128823..2130181 - 1359 WP_006190765.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IF777_RS10530 (IF777_10490) 2130196..2131266 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF777_RS10535 (IF777_10495) 2131584..2132786 + 1203 WP_045173480.1 FtsW/RodA/SpoVE family cell cycle protein -
IF777_RS10540 (IF777_10500) 2133050..2133187 - 138 WP_000828354.1 Lmo0850 family protein -
IF777_RS10545 (IF777_10505) 2133315..2133524 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF777_RS10550 (IF777_10510) 2133536..2133829 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF777_RS10555 (IF777_10515) 2133995..2135479 + 1485 WP_000571549.1 cardiolipin synthase -
IF777_RS10560 (IF777_10520) 2135507..2136154 + 648 WP_001187630.1 HD domain-containing protein -
IF777_RS10565 (IF777_10525) 2136620..2137492 - 873 WP_000725802.1 membrane protein insertase YidC -
IF777_RS10570 (IF777_10530) 2137578..2138219 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174868 WP_000581792.1 NZ_CP062399:c2133524-2133315 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174868 NZ_CP081698:3699842-3700183 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174868 WP_000138932.1 NZ_CP062399:c2133829-2133536 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174868 NZ_CP081698:3699504-3699821 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References