Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1958530..1959306 Replicon chromosome
Accession NZ_CP062399
Organism Staphylococcus aureus strain NAS_OP_143

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag IF777_RS09550 Protein ID WP_000031108.1
Coordinates 1958530..1958682 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag IF777_RS09555 Protein ID WP_001251224.1
Coordinates 1958707..1959306 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF777_RS09535 (IF777_09500) 1954653..1955474 + 822 WP_045174097.1 RluA family pseudouridine synthase -
IF777_RS09540 (IF777_09505) 1955892..1957277 - 1386 WP_045174099.1 class II fumarate hydratase -
IF777_RS09545 (IF777_09510) 1957473..1957868 - 396 WP_045174101.1 hypothetical protein -
IF777_RS09550 (IF777_09515) 1958530..1958682 - 153 WP_000031108.1 SAS053 family protein Toxin
IF777_RS09555 (IF777_09520) 1958707..1959306 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
IF777_RS09560 (IF777_09525) 1959464..1959934 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF777_RS09565 (IF777_09530) 1959939..1961066 - 1128 WP_240053230.1 tRNA epoxyqueuosine(34) reductase QueG -
IF777_RS09570 (IF777_09535) 1961217..1961939 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF777_RS09575 (IF777_09540) 1961932..1963389 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T174866 WP_000031108.1 NZ_CP062399:c1958682-1958530 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T174866 NZ_CP081698:2752623-2752730 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTACTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT174866 WP_001251224.1 NZ_CP062399:c1959306-1958707 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT174866 NZ_CP081698:c2752573-2752510 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References