Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 848455..848932 Replicon chromosome
Accession NZ_CP062399
Organism Staphylococcus aureus strain NAS_OP_143

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF777_RS04070 Protein ID WP_000052076.1
Coordinates 848455..848643 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF777_RS04075 Protein ID WP_001059690.1
Coordinates 848672..848932 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF777_RS04040 (IF777_04020) 844446..844967 + 522 WP_042909090.1 hypothetical protein -
IF777_RS04045 (IF777_04025) 845308..845994 + 687 WP_001792695.1 thermonuclease family protein -
IF777_RS04050 (IF777_04030) 846351..846551 + 201 WP_001059082.1 cold-shock protein -
IF777_RS04055 (IF777_04035) 847046..847264 - 219 WP_000005884.1 hypothetical protein -
IF777_RS04060 (IF777_04040) 847326..847610 - 285 WP_001004394.1 hypothetical protein -
IF777_RS04065 (IF777_04045) 847698..848267 - 570 WP_001106652.1 lipoprotein N-acylation protein LnsA -
IF777_RS04070 (IF777_04050) 848455..848643 - 189 WP_000052076.1 hypothetical protein Toxin
IF777_RS04075 (IF777_04055) 848672..848932 - 261 WP_001059690.1 hypothetical protein Antitoxin
IF777_RS04080 (IF777_04060) 849273..849476 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF777_RS04085 (IF777_04065) 849473..849709 - 237 WP_000368687.1 hypothetical protein -
IF777_RS04090 (IF777_04070) 849934..850515 + 582 WP_001140696.1 histidine phosphatase family protein -
IF777_RS04095 (IF777_04075) 850588..851205 - 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
IF777_RS04100 (IF777_04080) 851360..851854 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF777_RS04105 (IF777_04085) 852253..852675 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF777_RS04110 (IF777_04090) 852823..853539 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174864 WP_000052076.1 NZ_CP062399:c848643-848455 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174864 NZ_CP081698:2751552-2751659 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174864 WP_001059690.1 NZ_CP062399:c848932-848672 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174864 NZ_CP081698:c2751505-2751439 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References