Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2425611..2426134 Replicon chromosome
Accession NZ_CP062398
Organism Staphylococcus aureus strain NAS_OP_154

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag IF781_RS12035 Protein ID WP_000074049.1
Coordinates 2425611..2425877 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF781_RS12040 Protein ID WP_000587616.1
Coordinates 2425877..2426134 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF781_RS12015 (IF781_11955) 2420918..2422105 - 1188 WP_000026189.1 MFS transporter -
IF781_RS12020 (IF781_11960) 2422501..2423277 - 777 WP_031763862.1 iron export ABC transporter permease subunit FetB -
IF781_RS12025 (IF781_11965) 2423270..2423932 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
IF781_RS12030 (IF781_11970) 2424180..2425256 - 1077 WP_001076673.1 M42 family metallopeptidase -
IF781_RS12035 (IF781_11975) 2425611..2425877 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
IF781_RS12040 (IF781_11980) 2425877..2426134 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF781_RS12045 (IF781_11985) 2426493..2426948 + 456 WP_000732076.1 DUF1307 domain-containing protein -
IF781_RS12050 (IF781_11990) 2427116..2428693 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
IF781_RS12055 (IF781_11995) 2428888..2429637 + 750 WP_240022038.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T174863 WP_000074049.1 NZ_CP062398:c2425877-2425611 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174863 NZ_CP081698:c2531556-2531380 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174863 WP_000587616.1 NZ_CP062398:c2426134-2425877 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174863 NZ_CP081698:c2531334-2530918 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References