Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2052225..2052739 Replicon chromosome
Accession NZ_CP062398
Organism Staphylococcus aureus strain NAS_OP_154

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF781_RS10100 Protein ID WP_000581792.1
Coordinates 2052225..2052434 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF781_RS10105 Protein ID WP_000138932.1
Coordinates 2052446..2052739 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF781_RS10080 (IF781_10030) 2047733..2049091 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IF781_RS10085 (IF781_10035) 2049106..2050176 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF781_RS10090 (IF781_10040) 2050494..2051696 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF781_RS10095 (IF781_10045) 2051960..2052097 - 138 WP_000828354.1 Lmo0850 family protein -
IF781_RS10100 (IF781_10050) 2052225..2052434 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF781_RS10105 (IF781_10055) 2052446..2052739 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF781_RS10110 (IF781_10060) 2052905..2054389 + 1485 WP_000571549.1 cardiolipin synthase -
IF781_RS10115 (IF781_10065) 2054417..2055064 + 648 WP_001187630.1 HD domain-containing protein -
IF781_RS10120 (IF781_10070) 2055977..2056849 - 873 WP_000725802.1 membrane protein insertase YidC -
IF781_RS10125 (IF781_10075) 2056935..2057576 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174859 WP_000581792.1 NZ_CP062398:c2052434-2052225 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174859 NZ_CP081698:1015800-1016135 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAAGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174859 WP_000138932.1 NZ_CP062398:c2052739-2052446 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174859 NZ_CP081698:1015552-1015800 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References