Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 798687..799164 Replicon chromosome
Accession NZ_CP062398
Organism Staphylococcus aureus strain NAS_OP_154

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF781_RS03790 Protein ID WP_000052076.1
Coordinates 798687..798875 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF781_RS03795 Protein ID WP_001059690.1
Coordinates 798904..799164 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF781_RS03760 (IF781_03730) 794681..795202 + 522 WP_000824482.1 hypothetical protein -
IF781_RS03765 (IF781_03735) 795543..796229 + 687 WP_000141557.1 thermonuclease family protein -
IF781_RS03770 (IF781_03740) 796586..796786 + 201 WP_001059082.1 cold-shock protein -
IF781_RS03775 (IF781_03745) 797278..797496 - 219 WP_000005886.1 hypothetical protein -
IF781_RS03780 (IF781_03750) 797558..797842 - 285 WP_001004399.1 hypothetical protein -
IF781_RS03785 (IF781_03755) 797930..798499 - 570 WP_240022065.1 lipoprotein N-acylation protein LnsA -
IF781_RS03790 (IF781_03760) 798687..798875 - 189 WP_000052076.1 hypothetical protein Toxin
IF781_RS03795 (IF781_03765) 798904..799164 - 261 WP_001059690.1 hypothetical protein Antitoxin
IF781_RS03800 (IF781_03770) 799505..799708 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF781_RS03805 (IF781_03775) 799705..799941 - 237 WP_000349581.1 hypothetical protein -
IF781_RS03810 (IF781_03780) 800166..800747 + 582 WP_001140693.1 histidine phosphatase family protein -
IF781_RS03815 (IF781_03785) 800820..801437 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
IF781_RS03820 (IF781_03790) 801592..802086 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF781_RS03825 (IF781_03795) 802485..802907 - 423 WP_240022066.1 organic hydroperoxide resistance protein -
IF781_RS03830 (IF781_03800) 803055..803771 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterial toxin, RNase RnlA/LsoA, N-terminal repeated domain

(92-174)

Antitoxin

Antitoxin RnlB/LsoB

(20-114)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174854 WP_000052076.1 NZ_CP062398:c798875-798687 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174854 NZ_CP081696:c2607-1570 [Escherichia coli]
ATGGCACAGAACCCATTTAAAGCACTAAATATTAATACAGACAAGATTGAAGCTGCCTTGACGCAGAATGGCGTCACAAA
CTTTTCTTCTATCGTGAGAAACGAAAGAGAAACACATTTATCAGGGACATATAAAGAAATAGATTTTTTAATAAAGCTAA
TGCCATCAGGTGGAAACACCACTATAGGAAGGGCATCAGGACAAAACAACACTTACTTTGATGAGATCGCTGGCATTATA
AAAGAAAACTGTTTGTATTCAGATAAAAAAACGTTTGAATACACAATCCCAAGATTCAGCGATGAAAATAAGGAAATGTT
GTTTGCATTTCTTACTGAAGAAAACGTAAAAATAGAAGAAGATAAAAACAACGACCCCAACTGTAAACATCAATACATCA
TGACCACTGGCAATGGTGACAGAGTCAGAGCAAAAATTTACAACCGTGGCTCAATTCAATTCCAAGGTAAATATCTTCAA
ATCGCAAGTTTGATTAATGATTTCATGTGCACCATACTGGACATGAAAGAGATTATAGAACAGAAGAATCAAGAATTTAA
TGTTGACATAAAAAAAGAAACAATTGAGTCAGAATTACATAGTAAACTACCAAAAAGCATCGACCTAATCCATGACGACA
TCAAAAAACAGCTATCCTGCTCGCTCATAATGAAACAAATAGATGTCGAAATGGAAGATTACTCAACATATTGTTTCTCA
GCCTTAAGATCCATAGAAGGCTTTATATATCAACTACTTGGAAGCGTATGCAACCCATCATCATCAAGGAATCTTGGCGA
GTACTTCACTGAGAATAACCCGAAATACATAATAAGAGATATACACCAAGAAACTATTAATGGTGAAATAGCAGAAGTTT
TGTGTGAGTGCTACACTTACTGGCATGAAAACAGACATGGCTTGTTCCATATGAAACCAGGTGTGGCTGACACTAAGACA
ATTGACAAAGCAGAATCTATTGAAATTATCGATACTGTATGTCAGTTGATAGATAAAGGCATGGCTAGGTTGAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174854 WP_001059690.1 NZ_CP062398:c799164-798904 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174854 NZ_CP081696:c1570-1190 [Escherichia coli]
ATGAAAATAAACAAAAAATATCAAATAGAGGTGATAAAGGATAAAGATAAAACTTTGTTCATTGTCTACGCTACAGATAT
TTATAGCCCGAGCGAATTTTTCTCTAAAATCGAGTCTGATTTAAAGAAAAAGAAAGTTGGTGGCGATGTTTTTTTTGATT
TAATAATTCCTAATGGTGGAAAAAAAGACCGTTACGTCCATACATCATTCAACGGCGAGCGATTGACAAGCTACACATTA
AACAAAGTTACGGAAACAGATAAGTATAAATCCTTATCGGAACGCTCAGCTTCGTTCTTTAAGAATAACTTTAATAATAT
TAATGCAAACCTTCTATCTAAAGCCACATCATTTGCTTTAAAACAAGGTATTCCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References