174848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2650920..2651434 Replicon chromosome
Accession NZ_CP062395
Organism Staphylococcus aureus strain NAS_AN_005

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF694_RS12965 Protein ID WP_000581792.1
Coordinates 2651225..2651434 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF694_RS12960 Protein ID WP_000138932.1
Coordinates 2650920..2651213 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF694_RS12940 (IF694_12795) 2646365..2647006 + 642 WP_064138554.1 thiamine phosphate synthase -
IF694_RS12945 (IF694_12800) 2647092..2647964 + 873 WP_000725802.1 membrane protein insertase YidC -
IF694_RS12950 (IF694_12805) 2648595..2649242 - 648 WP_001187620.1 HD domain-containing protein -
IF694_RS12955 (IF694_12810) 2649270..2650754 - 1485 WP_000571551.1 cardiolipin synthase -
IF694_RS12960 (IF694_12815) 2650920..2651213 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF694_RS12965 (IF694_12820) 2651225..2651434 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF694_RS12970 (IF694_12825) 2651562..2651699 + 138 WP_000828354.1 Lmo0850 family protein -
IF694_RS12975 (IF694_12830) 2651963..2653165 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF694_RS12980 (IF694_12835) 2653483..2654553 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF694_RS12985 (IF694_12840) 2654568..2655926 + 1359 WP_047213666.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174848 WP_000581792.1 NZ_CP062395:2651225-2651434 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174848 NZ_CP081690:c4488200-4488027 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174848 WP_000138932.1 NZ_CP062395:2650920-2651213 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174848 NZ_CP081690:c4488524-4488228 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References