Detailed information of TA system TA174839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1196888..1197365
• Replicon: chromosome
• Accession: NZ_CP062395
• Organism: Staphylococcus aureus strain NAS_AN_005

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF694_RS05960
• Protein ID: WP_000052076.1
• Coordinates: 1197177..1197365 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF694_RS05955
• Protein ID: WP_001059690.1
• Coordinates: 1196888..1197148 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF694_RS05920 (IF694_05845)	1192444..1192938	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
IF694_RS05925 (IF694_05850)	1193153..1194472	+	1320	WP_001807150.1	ISL3-like element IS1181 family transposase	-
IF694_RS05930	1194475..1194546	+	72	Protein_1141	hypothetical protein	-
IF694_RS05935 (IF694_05855)	1194615..1195232	+	618	WP_047213256.1	LysE/ArgO family amino acid transporter	-
IF694_RS05940 (IF694_05860)	1195305..1195886	-	582	WP_001140691.1	histidine phosphatase family protein	-
IF694_RS05945 (IF694_05865)	1196111..1196347	+	237	WP_000368687.1	hypothetical protein	-
IF694_RS05950 (IF694_05870)	1196344..1196547	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF694_RS05955 (IF694_05875)	1196888..1197148	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF694_RS05960 (IF694_05880)	1197177..1197365	+	189	WP_000052076.1	hypothetical protein	Toxin
IF694_RS05965 (IF694_05885)	1197553..1198122	+	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
IF694_RS05970 (IF694_05890)	1198210..1198494	+	285	WP_001004397.1	hypothetical protein	-
IF694_RS05975 (IF694_05895)	1198556..1198774	+	219	WP_000005883.1	hypothetical protein	-
IF694_RS05980 (IF694_05900)	1199271..1199471	-	201	WP_001059082.1	cold-shock protein	-
IF694_RS05985 (IF694_05905)	1199828..1200514	-	687	WP_000141556.1	thermonuclease family protein	-
IF694_RS05990 (IF694_05910)	1200855..1201337	-	483	WP_000824492.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1193153..1194472	1319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-134)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174839 WP_000052076.1 NZ_CP062395:1197177-1197365 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174839 NZ_CP081690:c2704137-2703961 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174839 WP_001059690.1 NZ_CP062395:1196888-1197148 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174839 NZ_CP081690:c2703915-2703499 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56