Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2694914..2695428 Replicon chromosome
Accession NZ_CP062393
Organism Staphylococcus aureus strain NAS_AN_009

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF695_RS13400 Protein ID WP_000581792.1
Coordinates 2695219..2695428 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF695_RS13395 Protein ID WP_000138932.1
Coordinates 2694914..2695207 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF695_RS13375 (2690177) 2690177..2690818 + 642 WP_000483153.1 thiamine phosphate synthase -
IF695_RS13380 (2690904) 2690904..2691776 + 873 WP_000725802.1 membrane protein insertase YidC -
IF695_RS13385 (2692589) 2692589..2693236 - 648 WP_001187629.1 HD domain-containing protein -
IF695_RS13390 (2693264) 2693264..2694748 - 1485 WP_000571549.1 cardiolipin synthase -
IF695_RS13395 (2694914) 2694914..2695207 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF695_RS13400 (2695219) 2695219..2695428 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF695_RS13405 (2695556) 2695556..2695693 + 138 WP_000828354.1 Lmo0850 family protein -
IF695_RS13410 (2695957) 2695957..2697159 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF695_RS13415 (2697477) 2697477..2698547 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF695_RS13420 (2698562) 2698562..2699920 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174836 WP_000581792.1 NZ_CP062393:2695219-2695428 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174836 NZ_CP081690:1968763-1969017 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174836 WP_000138932.1 NZ_CP062393:2694914-2695207 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174836 NZ_CP081690:1968515-1968766 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References