Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1210336..1210813 Replicon chromosome
Accession NZ_CP062393
Organism Staphylococcus aureus strain NAS_AN_009

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag IF695_RS06130 Protein ID WP_000052078.1
Coordinates 1210625..1210813 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF695_RS06125 Protein ID WP_001059690.1
Coordinates 1210336..1210596 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF695_RS06090 (1205729) 1205729..1206445 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
IF695_RS06095 (1206593) 1206593..1207015 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF695_RS06100 (1207414) 1207414..1207908 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF695_RS06105 (1208063) 1208063..1208680 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF695_RS06110 (1208753) 1208753..1209334 - 582 WP_001140686.1 histidine phosphatase family protein -
IF695_RS06115 (1209559) 1209559..1209795 + 237 WP_000368687.1 hypothetical protein -
IF695_RS06120 (1209792) 1209792..1209995 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF695_RS06125 (1210336) 1210336..1210596 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF695_RS06130 (1210625) 1210625..1210813 + 189 WP_000052078.1 hypothetical protein Toxin
IF695_RS06135 (1211001) 1211001..1211570 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF695_RS06140 (1211658) 1211658..1211942 + 285 WP_001004395.1 hypothetical protein -
IF695_RS06145 (1212004) 1212004..1212222 + 219 WP_000005886.1 hypothetical protein -
IF695_RS06150 (1212718) 1212718..1212918 - 201 WP_001059082.1 cold-shock protein -
IF695_RS06155 (1213275) 1213275..1213961 - 687 WP_001548082.1 thermonuclease family protein -
IF695_RS06160 (1214302) 1214302..1214772 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T174827 WP_000052078.1 NZ_CP062393:1210625-1210813 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174827 NZ_CP081687:19409-19720 [Escherichia coli]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174827 WP_001059690.1 NZ_CP062393:1210336-1210596 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174827 NZ_CP081687:19717-20136 [Escherichia coli]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTTCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References