Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2680006..2680520 Replicon chromosome
Accession NZ_CP062390
Organism Staphylococcus aureus strain NAS_AN_036

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF699_RS13295 Protein ID WP_000581792.1
Coordinates 2680311..2680520 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF699_RS13290 Protein ID WP_000138932.1
Coordinates 2680006..2680299 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF699_RS13270 (2675370) 2675370..2676011 + 642 WP_000483156.1 thiamine phosphate synthase -
IF699_RS13275 (2676097) 2676097..2676969 + 873 WP_000725800.1 membrane protein insertase YidC -
IF699_RS13280 (2677681) 2677681..2678328 - 648 WP_001187630.1 HD domain-containing protein -
IF699_RS13285 (2678356) 2678356..2679840 - 1485 WP_000571549.1 cardiolipin synthase -
IF699_RS13290 (2680006) 2680006..2680299 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF699_RS13295 (2680311) 2680311..2680520 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF699_RS13300 (2680648) 2680648..2680785 + 138 WP_000828354.1 Lmo0850 family protein -
IF699_RS13305 (2681049) 2681049..2682251 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF699_RS13310 (2682569) 2682569..2683639 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF699_RS13315 (2683654) 2683654..2685012 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174818 WP_000581792.1 NZ_CP062390:2680311-2680520 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174818 NZ_CP081684:c4150116-4149802 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174818 WP_000138932.1 NZ_CP062390:2680006-2680299 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174818 NZ_CP081684:c4150352-4150119 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References