Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1196273..1196750 Replicon chromosome
Accession NZ_CP062390
Organism Staphylococcus aureus strain NAS_AN_036

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF699_RS06075 Protein ID WP_000052076.1
Coordinates 1196562..1196750 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF699_RS06070 Protein ID WP_001059690.1
Coordinates 1196273..1196533 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF699_RS06035 (1191666) 1191666..1192382 - 717 WP_000150019.1 type I 3-dehydroquinate dehydratase -
IF699_RS06040 (1192530) 1192530..1192952 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF699_RS06045 (1193351) 1193351..1193845 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF699_RS06050 (1194000) 1194000..1194617 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
IF699_RS06055 (1194690) 1194690..1195271 - 582 WP_001140697.1 histidine phosphatase family protein -
IF699_RS06060 (1195496) 1195496..1195732 + 237 WP_000368687.1 hypothetical protein -
IF699_RS06065 (1195729) 1195729..1195932 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF699_RS06070 (1196273) 1196273..1196533 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF699_RS06075 (1196562) 1196562..1196750 + 189 WP_000052076.1 hypothetical protein Toxin
IF699_RS06080 (1196938) 1196938..1197507 + 570 WP_001106652.1 lipoprotein N-acylation protein LnsA -
IF699_RS06085 (1197595) 1197595..1197879 + 285 WP_001004394.1 hypothetical protein -
IF699_RS06090 (1197941) 1197941..1198166 + 226 Protein_1176 hypothetical protein -
IF699_RS06095 (1198661) 1198661..1198861 - 201 WP_001059082.1 cold-shock protein -
IF699_RS06100 (1199218) 1199218..1199904 - 687 WP_001566557.1 thermonuclease family protein -
IF699_RS06105 (1200245) 1200245..1200715 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174809 WP_000052076.1 NZ_CP062390:1196562-1196750 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174809 NZ_CP081684:1968515-1968766 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174809 WP_001059690.1 NZ_CP062390:1196273-1196533 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174809 NZ_CP081684:1968763-1969017 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References