Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2664219..2664748 Replicon chromosome
Accession NZ_CP062388
Organism Staphylococcus aureus strain NAS_AN_044

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF700_RS13135 Protein ID WP_000621175.1
Coordinates 2664386..2664748 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF700_RS13130 Protein ID WP_000948331.1
Coordinates 2664219..2664389 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF700_RS13100 (2659256) 2659256..2659816 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
IF700_RS13105 (2660024) 2660024..2660503 + 480 WP_001287087.1 hypothetical protein -
IF700_RS13110 (2660496) 2660496..2662079 + 1584 WP_001294626.1 PH domain-containing protein -
IF700_RS13115 (2662066) 2662066..2662557 + 492 WP_001205912.1 PH domain-containing protein -
IF700_RS13120 (2662561) 2662561..2662920 + 360 WP_000581197.1 holo-ACP synthase -
IF700_RS13125 (2662986) 2662986..2664134 + 1149 WP_001281154.1 alanine racemase -
IF700_RS13130 (2664219) 2664219..2664389 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF700_RS13135 (2664386) 2664386..2664748 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF700_RS13140 (2665097) 2665097..2666098 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF700_RS13145 (2666217) 2666217..2666543 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF700_RS13150 (2666545) 2666545..2667024 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IF700_RS13155 (2666999) 2666999..2667769 + 771 WP_001041111.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174801 WP_000621175.1 NZ_CP062388:2664386-2664748 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174801 NZ_CP081682:1505-2542 [Escherichia coli]
ATGGCACAGAACCCATTTAAAGCACTAAATATTAATACAGACAAGATTGAAGCTGCCTTGACGCAGAATGGCGTCACAAA
CTTTTCTTCTATCGTGAGAAACGAAAGAGAAACACATTTATCAGGGACATATAAAGAAATAGATTTTTTAATAAAGCTAA
TGCCATCAGGTGGAAACACCACTATAGGAAGGGCATCAGGACAAAACAACACTTACTTTGATGAGATCGCTGGCATTATA
AAAGAAAACTGTTTGTATTCAGATAAAAAAACGTTTGAATACACAATCCCAAGATTCAGCGATGAAAATAAGGAAATGTT
GTTTGCATTTCTTACTGAAGAAAACGTAAAAATAGAAGAAGATAAAAACAACGACCCCAACTGTAAACATCAATACATCA
TGACCACTGGCAATGGTGACAGAGTCAGAGCAAAAATTTACAACCGTGGCTCAATTCAATTCCAAGGTAAATATCTTCAA
ATCGCAAGTTTGATTAATGATTTCATGTGCACCATACTGGACATGAAAGAGATTATAGAACAGAAGAATCAAGAATTTAA
TGTTGACATAAAAAAAGAAACAATTGAGTCAGAATTACATAGTAAACTACCAAAAAGCATCGACCTAATCCATGACGACA
TCAAAAAACAGCTATCCTGCTCGCTCATAATGAAACAAATAGATGTCGAAATGGAAGATTACTCAACATATTGTTTCTCA
GCCTTAAGATCCATAGAAGGCTTTATATATCAACTACTTGGAAGCGTATGCAACCCATCATCATCAAGGAATCTTGGCGA
GTACTTCACTGAGAATAACCCGAAATACATAATAAGAGATATACACCAAGAAACTATTAATGGTGAAATAGCAGAAGTTT
TGTGTGAGTGCTACACTTACTGGCATGAAAACAGACATGGCTTGTTCCATATGAAACCAGGTGTGGCTGACACTAAGACA
ATTGACAAAGCAGAATCTATTGAAATTATCGATACTGTATGTCAGTTGATAGATAAAGGCATGGCTAGGTTGAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174801 WP_000948331.1 NZ_CP062388:2664219-2664389 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174801 NZ_CP081682:2542-2922 [Escherichia coli]
ATGAAAATAAACAAAAAATATCAAATAGAGGTGATAAAGGATAAAGATAAAACTTTGTTCATTGTCTACGCTACAGATAT
TTATAGCCCGAGCGAATTTTTCTCTAAAATCGAGTCTGATTTAAAGAAAAAGAAAGTTGGTGGCGATGTTTTTTTTGATT
TAATAATTCCTAATGGTGGAAAAAAAGACCGTTACGTCCATACATCATTCAACGGCGAGCGATTGACAAGCTACACATTA
AACAAAGTTACGGAAACAGATAAGTATAAATCCTTATCGGAACGCTCAGCTTCGTTCTTTAAGAATAACTTTAATAATAT
TAATGCAAACCTTCTATCTAAAGCCACATCATTTGCTTTAAAACAAGGTATTCCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References