174800

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2642975..2643489 Replicon chromosome
Accession NZ_CP062388
Organism Staphylococcus aureus strain NAS_AN_044

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF700_RS13035 Protein ID WP_000581792.1
Coordinates 2643280..2643489 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF700_RS13030 Protein ID WP_000138932.1
Coordinates 2642975..2643268 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF700_RS13010 (2638138) 2638138..2638779 + 642 WP_000483153.1 thiamine phosphate synthase -
IF700_RS13015 (2638865) 2638865..2639737 + 873 WP_000725802.1 membrane protein insertase YidC -
IF700_RS13020 (2640650) 2640650..2641297 - 648 WP_001187630.1 HD domain-containing protein -
IF700_RS13025 (2641325) 2641325..2642809 - 1485 WP_000571549.1 cardiolipin synthase -
IF700_RS13030 (2642975) 2642975..2643268 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF700_RS13035 (2643280) 2643280..2643489 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF700_RS13040 (2643617) 2643617..2643754 + 138 WP_000828354.1 Lmo0850 family protein -
IF700_RS13045 (2644018) 2644018..2645220 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF700_RS13050 (2645538) 2645538..2646608 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF700_RS13055 (2646623) 2646623..2647981 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174800 WP_000581792.1 NZ_CP062388:2643280-2643489 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174800 NZ_CP081680:23072-23383 [Escherichia coli]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174800 WP_000138932.1 NZ_CP062388:2642975-2643268 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174800 NZ_CP081680:23380-23799 [Escherichia coli]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTTCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References