Detailed information of TA system TA174791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1152927..1153404
• Replicon: chromosome
• Accession: NZ_CP062388
• Organism: Staphylococcus aureus strain NAS_AN_044

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF700_RS05740
• Protein ID: WP_000052076.1
• Coordinates: 1153216..1153404 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF700_RS05735
• Protein ID: WP_001059690.1
• Coordinates: 1152927..1153187 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF700_RS05700 (1148320)	1148320..1149036	-	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-
IF700_RS05705 (1149184)	1149184..1149606	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF700_RS05710 (1150005)	1150005..1150499	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF700_RS05715 (1150654)	1150654..1151271	+	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
IF700_RS05720 (1151344)	1151344..1151925	-	582	WP_001140693.1	histidine phosphatase family protein	-
IF700_RS05725 (1152150)	1152150..1152386	+	237	WP_000349581.1	hypothetical protein	-
IF700_RS05730 (1152383)	1152383..1152586	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF700_RS05735 (1152927)	1152927..1153187	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IF700_RS05740 (1153216)	1153216..1153404	+	189	WP_000052076.1	hypothetical protein	Toxin
IF700_RS05745 (1153592)	1153592..1154161	+	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
IF700_RS05750 (1154249)	1154249..1154533	+	285	WP_001004399.1	hypothetical protein	-
IF700_RS05755 (1154595)	1154595..1154813	+	219	WP_000005886.1	hypothetical protein	-
IF700_RS05760 (1155305)	1155305..1155505	-	201	WP_001059082.1	cold-shock protein	-
IF700_RS05765 (1155862)	1155862..1156548	-	687	WP_000141557.1	thermonuclease family protein	-
IF700_RS05770 (1156889)	1156889..1157410	-	522	WP_000824482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	1149184..1187155	37971

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (8-77)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174791 WP_000052076.1 NZ_CP062388:1153216-1153404 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174791 NZ_CP081677:c4150117-4149803 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174791 WP_001059690.1 NZ_CP062388:1152927-1153187 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174791 NZ_CP081677:c4150353-4150120 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56