Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 122571..123347 Replicon chromosome
Accession NZ_CP062388
Organism Staphylococcus aureus strain NAS_AN_044

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag IF700_RS00790 Protein ID WP_000031108.1
Coordinates 123195..123347 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag IF700_RS00785 Protein ID WP_001251224.1
Coordinates 122571..123170 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF700_RS00765 (118487) 118487..119944 + 1458 WP_000649908.1 ABC transporter permease subunit -
IF700_RS00770 (119937) 119937..120659 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF700_RS00775 (120810) 120810..121937 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
IF700_RS00780 (121942) 121942..122412 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF700_RS00785 (122571) 122571..123170 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
IF700_RS00790 (123195) 123195..123347 + 153 WP_000031108.1 SAS053 family protein Toxin
IF700_RS00795 (123895) 123895..124290 + 396 WP_000901023.1 hypothetical protein -
IF700_RS00800 (124486) 124486..125871 + 1386 WP_000116228.1 class II fumarate hydratase -
IF700_RS00805 (126324) 126324..127145 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T174788 WP_000031108.1 NZ_CP062388:123195-123347 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T174788 NZ_CP081677:2935550-2935657 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT174788 WP_001251224.1 NZ_CP062388:122571-123170 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT174788 NZ_CP081677:c2935500-2935437 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References