Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1172161..1172638 Replicon chromosome
Accession NZ_CP062386
Organism Staphylococcus aureus strain NAS_AN_047

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF701_RS05820 Protein ID WP_000052076.1
Coordinates 1172450..1172638 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF701_RS05815 Protein ID WP_001059690.1
Coordinates 1172161..1172421 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF701_RS05780 (1167554) 1167554..1168270 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
IF701_RS05785 (1168418) 1168418..1168840 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF701_RS05790 (1169239) 1169239..1169733 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF701_RS05795 (1169888) 1169888..1170505 + 618 WP_196495160.1 LysE/ArgO family amino acid transporter -
IF701_RS05800 (1170578) 1170578..1171159 - 582 WP_001140693.1 histidine phosphatase family protein -
IF701_RS05805 (1171384) 1171384..1171620 + 237 WP_000368687.1 hypothetical protein -
IF701_RS05810 (1171617) 1171617..1171820 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF701_RS05815 (1172161) 1172161..1172421 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF701_RS05820 (1172450) 1172450..1172638 + 189 WP_000052076.1 hypothetical protein Toxin
IF701_RS05825 (1172826) 1172826..1173395 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF701_RS05830 (1173483) 1173483..1173767 + 285 WP_001004395.1 hypothetical protein -
IF701_RS05835 (1173829) 1173829..1174047 + 219 WP_000005886.1 hypothetical protein -
IF701_RS05840 (1174543) 1174543..1174743 - 201 WP_001059082.1 cold-shock protein -
IF701_RS05845 (1175100) 1175100..1175786 - 687 WP_001792695.1 thermonuclease family protein -
IF701_RS05850 (1176127) 1176127..1176648 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-140)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174773 WP_000052076.1 NZ_CP062386:1172450-1172638 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174773 NZ_CP081673:c3406447-3405869 [Mycolicibacterium farcinogenes]
GTGAAGCGCCTCGATCTCGTCGTCGGCTGCAACGGCGCCGGCAAGTCGACCTTCGTCGAACTCACCCTCTCACCTCTGCT
GCCCGGCAGCCCGTTCGTCAACGCGGACGAAATCGCCAAGCGGCGGTGGCCCGAAGACCCTGCCCCGCACTCGTATGAAG
CCGCGTTGATCGCGGCCGAAACCCGCGCGAAACTCATCGAACTCGGTGAGTCGTTCATCGCCGAAACCGTGTTCTCGCAC
CCTTCCAAGCTCGACCTCATCGACGACGCACACATCGCCGGGTACACCGTGGTGCTGCACTGCATCCTCATCCCCGAAGA
ATTGGCCGTGCAGCGCGTGCGTCACCGGGTGTCGGCGGGTGGCCACGACGTGCCTGAAGCCAAGATCCGCGAGCGCTACC
AACGGCTTTGGGACCTGGTCGCCGTCGCCGCGATGCGCGCGGACGCCGCAACGTTCTACGACAACAGCACCGTCAGAGGC
CCCCGCATCGTCGCCCAGATAGCGGGCGGTTTCGCCATCGGTTCGCCCACCTGGCCGAAATGGGCACCGGCGGTGCTCAT
TTCACGCTGGGCGGGTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174773 WP_001059690.1 NZ_CP062386:1172161-1172421 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174773 NZ_CP081673:c3406874-3406485 [Mycolicibacterium farcinogenes]
ATGACGGAGACCGCAGACCGGGTCACCCGGTTCGCCGCTGATCTCATCGATAGTGCGGCCGCCGAAGGCGCACGTCAGAG
CCGGTCAGCCAAACAGCAGCTCGACCACTGGGCTCGAGTGGGCCGGGCCGTGTCCAGCCAACACAGTGCGGCACGCCGCA
AGGTGGAGTCCGCGTTGGCCGGCGAGTTGTCCCTGCGTGAGTTGACGGCCGAAGAAGGCACGGTGTTCGACGCCGAGATC
GCCGCCTCCATCGAGGAAAGCCTGGCGCGTGCCGACTACGGCAAGACGCTGGCCGGACGCGGAATCACCACGGTGGCGCT
CGACGACAACGGCAACATCGTGCAGTACCGTCCCGACGGCAGCACTGCGGTGCTGGCGCGCACGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References