Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2650142..2650671 Replicon chromosome
Accession NZ_CP062384
Organism Staphylococcus aureus strain NAS_AN_050

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF702_RS13000 Protein ID WP_000621175.1
Coordinates 2650309..2650671 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF702_RS12995 Protein ID WP_000948331.1
Coordinates 2650142..2650312 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF702_RS12965 (2645179) 2645179..2645739 + 561 WP_001092406.1 K(+)-transporting ATPase subunit C -
IF702_RS12970 (2645947) 2645947..2646426 + 480 WP_001287077.1 hypothetical protein -
IF702_RS12975 (2646419) 2646419..2648002 + 1584 WP_001294637.1 PH domain-containing protein -
IF702_RS12980 (2647989) 2647989..2648480 + 492 WP_001205907.1 PH domain-containing protein -
IF702_RS12985 (2648484) 2648484..2648843 + 360 WP_000581199.1 holo-ACP synthase -
IF702_RS12990 (2648909) 2648909..2650057 + 1149 WP_001281140.1 alanine racemase -
IF702_RS12995 (2650142) 2650142..2650312 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF702_RS13000 (2650309) 2650309..2650671 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF702_RS13005 (2651020) 2651020..2652021 + 1002 WP_042744356.1 PP2C family protein-serine/threonine phosphatase -
IF702_RS13010 (2652140) 2652140..2652466 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF702_RS13015 (2652468) 2652468..2652947 + 480 WP_001190825.1 anti-sigma B factor RsbW -
IF702_RS13020 (2652922) 2652922..2653692 + 771 WP_221575077.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174766 WP_000621175.1 NZ_CP062384:2650309-2650671 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174766 NZ_CP081505:2790766-2790906 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174766 WP_000948331.1 NZ_CP062384:2650142-2650312 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174766 NZ_CP081505:c2790764-2790621 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References