Detailed information of TA system TA174762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1168298..1168827
• Replicon: chromosome
• Accession: NZ_CP062384
• Organism: Staphylococcus aureus strain NAS_AN_050

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: IF702_RS05840
• Protein ID: WP_001103939.1
• Coordinates: 1168298..1168615 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: IF702_RS05845
• Protein ID: WP_001058494.1
• Coordinates: 1168618..1168827 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF702_RS13590 (1163923)	1163923..1164057	-	135	WP_256094151.1	hypothetical protein	-
IF702_RS05815 (1164304)	1164304..1164945	-	642	WP_001019808.1	hypothetical protein	-
IF702_RS05820 (1164942)	1164942..1165226	-	285	WP_000998185.1	hypothetical protein	-
IF702_RS05825 (1165228)	1165228..1165590	-	363	WP_001039170.1	hypothetical protein	-
IF702_RS05830 (1165891)	1165891..1167348	-	1458	WP_000390453.1	virulence-associated E family protein	-
IF702_RS05835 (1167365)	1167365..1168234	-	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
IF702_RS05840 (1168298)	1168298..1168615	-	318	WP_001103939.1	DUF1474 family protein	Toxin
IF702_RS05845 (1168618)	1168618..1168827	-	210	WP_001058494.1	hypothetical protein	Antitoxin
IF702_RS05850 (1168820)	1168820..1168966	-	147	WP_000784885.1	hypothetical protein	-
IF702_RS05855 (1168978)	1168978..1169196	-	219	WP_000163544.1	helix-turn-helix transcriptional regulator	-
IF702_RS05860 (1169232)	1169232..1169435	-	204	WP_001045296.1	transcriptional regulator	-
IF702_RS05865 (1169571)	1169571..1170374	+	804	WP_000358990.1	helix-turn-helix transcriptional regulator	-
IF702_RS05870 (1170364)	1170364..1171470	+	1107	WP_000149511.1	tyrosine-type recombinase/integrase	-
IF702_RS05880 (1172033)	1172033..1172497	-	465	WP_001085185.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sell / sec	1153149..1174891	21742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T174762 WP_001103939.1 NZ_CP062384:c1168615-1168298 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T174762 NZ_CP081505:c2342849-2342733 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT174762 WP_001058494.1 NZ_CP062384:c1168827-1168618 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT174762 NZ_CP081505:2342617-2342822 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTTTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59