Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1140227..1140704 Replicon chromosome
Accession NZ_CP062384
Organism Staphylococcus aureus strain NAS_AN_050

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF702_RS05680 Protein ID WP_000052076.1
Coordinates 1140516..1140704 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF702_RS05675 Protein ID WP_001059690.1
Coordinates 1140227..1140487 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF702_RS05640 (1135620) 1135620..1136336 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
IF702_RS05645 (1136484) 1136484..1136906 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
IF702_RS05650 (1137305) 1137305..1137799 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF702_RS05655 (1137955) 1137955..1138572 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
IF702_RS05660 (1138645) 1138645..1139226 - 582 WP_001140696.1 histidine phosphatase family protein -
IF702_RS05665 (1139450) 1139450..1139686 + 237 WP_000368687.1 hypothetical protein -
IF702_RS05670 (1139683) 1139683..1139886 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
IF702_RS05675 (1140227) 1140227..1140487 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF702_RS05680 (1140516) 1140516..1140704 + 189 WP_000052076.1 hypothetical protein Toxin
IF702_RS05685 (1140892) 1140892..1141461 + 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
IF702_RS05690 (1141549) 1141549..1141821 + 273 WP_001004400.1 hypothetical protein -
IF702_RS05695 (1141894) 1141894..1142112 + 219 WP_000005884.1 hypothetical protein -
IF702_RS05700 (1142609) 1142609..1142809 - 201 WP_001059082.1 cold-shock protein -
IF702_RS05705 (1143166) 1143166..1143852 - 687 WP_001622483.1 thermonuclease family protein -
IF702_RS05710 (1144193) 1144193..1144714 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174761 WP_000052076.1 NZ_CP062384:1140516-1140704 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174761 NZ_CP081505:c332592-332497 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174761 WP_001059690.1 NZ_CP062384:1140227-1140487 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174761 NZ_CP081505:332398-332462 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References