Detailed information of TA system TA174760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 120394..121170
• Replicon: chromosome
• Accession: NZ_CP062384
• Organism: Staphylococcus aureus strain NAS_AN_050

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: IF702_RS00770
• Protein ID: WP_000031109.1
• Coordinates: 121018..121170 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: IF702_RS00765
• Protein ID: WP_001251224.1
• Coordinates: 120394..120993 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF702_RS00745 (116310)	116310..117767	+	1458	WP_000649916.1	ABC transporter permease subunit	-
IF702_RS00750 (117760)	117760..118482	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
IF702_RS00755 (118633)	118633..119760	+	1128	WP_000379990.1	tRNA epoxyqueuosine(34) reductase QueG	-
IF702_RS00760 (119765)	119765..120235	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
IF702_RS00765 (120394)	120394..120993	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
IF702_RS00770 (121018)	121018..121170	+	153	WP_000031109.1	SAS053 family protein	Toxin
IF702_RS00775 (121996)	121996..122391	+	396	WP_000901019.1	hypothetical protein	-
IF702_RS00780 (122587)	122587..123972	+	1386	WP_000116239.1	class II fumarate hydratase	-
IF702_RS00785 (124429)	124429..125250	-	822	WP_000669377.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5950.31 Da
• Isoelectric Point: 3.9075

>T174760 WP_000031109.1 NZ_CP062384:121018-121170 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Nucleotide

• Length: 153 bp

>T174760 NZ_CP081502:1195345-1195605 [Streptococcus halichoeri]
ATGTATCATATAGAGTATTCTAAAAAAGCTCAAAAGCAAATTAAGAAACTAGATAAGCAGATTCAGAGATTGCTGTTTTC
CTGGATTGATAAGCATTTAGAAGGAACAGATAACCCCCGTGCCAATGGTAAAGGCTTGACAGGTAATCATGCTAACGAAT
GGCGTTATCGTATTGGTAATTATAGGCTTATTTGTGATATTCAAGATAATAAGATGATTATCTTAGCACTTGAGTTTGGA
CATAGGGGCGATATTTATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT174760 WP_001251224.1 NZ_CP062384:120394-120993 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT174760 NZ_CP081502:1195122-1195343 [Streptococcus halichoeri]
ATGAGTACTGTTACTATCAGATTGAATCAAGAAGAAGAAGTATTTTTCAAAAGCTATGCTCAATTAACAGGGCAAAGCCT
ATCAAGCCTCTTTAAGAAAGCTCTTGAGCGTGATATTGAAGATAAATATGATTTGAAAGTCTATAATCAAGCTTATGCAG
AATATAAAGCAGATCCACAGACAATTAGCCATGCTGACTTTAAGAAAGAGCTAGACTTATAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4