Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2769051..2769565 Replicon chromosome
Accession NZ_CP062382
Organism Staphylococcus aureus strain NAS_AN_068

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF703_RS13850 Protein ID WP_000581792.1
Coordinates 2769356..2769565 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF703_RS13845 Protein ID WP_000138932.1
Coordinates 2769051..2769344 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF703_RS13825 (2764496) 2764496..2765137 + 642 WP_000483160.1 thiamine phosphate synthase -
IF703_RS13830 (2765223) 2765223..2766095 + 873 WP_000725802.1 membrane protein insertase YidC -
IF703_RS13835 (2766726) 2766726..2767373 - 648 WP_001187620.1 HD domain-containing protein -
IF703_RS13840 (2767401) 2767401..2768885 - 1485 WP_000571551.1 cardiolipin synthase -
IF703_RS13845 (2769051) 2769051..2769344 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF703_RS13850 (2769356) 2769356..2769565 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF703_RS13855 (2769693) 2769693..2769830 + 138 WP_000828354.1 Lmo0850 family protein -
IF703_RS13860 (2770094) 2770094..2771296 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF703_RS13865 (2771614) 2771614..2772684 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF703_RS13870 (2772699) 2772699..2774057 + 1359 WP_047213666.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174754 WP_000581792.1 NZ_CP062382:2769356-2769565 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174754 NZ_CP081490:6137153-6137455 [Pseudomonas protegens]
ATGTACGTCTTCGAGCAGACCCTGGAGTTCAGCCGCTGGCTCCTGCACCTGAAGGATCCGCAAGGCAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCCCAACTGGGCCGATTCGGCGACTGCGAACCGGTAGGCGAAGGTGTCTATGAAATGCGCATCC
ATCGCGGCCCCGGCTATCGGGTGTACTTCTCGCGCCGGAACACCGTGATCTACCTGTTGTTGATCGGCGGTGACAAGGGC
ACCCAGAGACGCGATATCCAACGCGCCAGGCAACTGGCCCACGACCTCAAGAGCGAGGGTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174754 WP_000138932.1 NZ_CP062382:2769051-2769344 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174754 NZ_CP081490:6137459-6137749 [Pseudomonas protegens]
ATGCACACCCCAGTGACCCGCTTCGACGCGGCAGAGTACCTCAAGACCCCGGAAGACATGGTGGCCTACCTCGACGCCTG
CTTCGAGGAAGATGCCGGCGACGGCAAGCTGATCCGCGCCGCCCTCAACGACATCGCCCGCGCCCGGGGCATGACCCAGG
TGGCCCGCGACACCGGCCTGGGTCGAGAGAGTCTGTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCGACTATC
ATCAAGGTCATGAAGGCACTGGGACTCAAGCTCCACGTCAGCCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References