174746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1304792..1305269 Replicon chromosome
Accession NZ_CP062382
Organism Staphylococcus aureus strain NAS_AN_068

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF703_RS06750 Protein ID WP_000052076.1
Coordinates 1305081..1305269 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF703_RS06745 Protein ID WP_001059690.1
Coordinates 1304792..1305052 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF703_RS06710 (1300183) 1300183..1300899 - 717 WP_031927536.1 type I 3-dehydroquinate dehydratase -
IF703_RS06715 (1301047) 1301047..1301469 + 423 WP_031927537.1 organic hydroperoxide resistance protein -
IF703_RS06720 (1301868) 1301868..1302362 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
IF703_RS06725 (1302519) 1302519..1303136 + 618 WP_047213256.1 LysE/ArgO family amino acid transporter -
IF703_RS06730 (1303209) 1303209..1303790 - 582 WP_001140691.1 histidine phosphatase family protein -
IF703_RS06735 (1304015) 1304015..1304251 + 237 WP_000368687.1 hypothetical protein -
IF703_RS06740 (1304248) 1304248..1304451 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF703_RS06745 (1304792) 1304792..1305052 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF703_RS06750 (1305081) 1305081..1305269 + 189 WP_000052076.1 hypothetical protein Toxin
IF703_RS06755 (1305457) 1305457..1306026 + 570 WP_001106648.1 lipoprotein N-acylation protein LnsA -
IF703_RS06760 (1306114) 1306114..1306398 + 285 WP_001004397.1 hypothetical protein -
IF703_RS06765 (1306460) 1306460..1306678 + 219 WP_000005883.1 hypothetical protein -
IF703_RS06770 (1307175) 1307175..1307375 - 201 WP_001059082.1 cold-shock protein -
IF703_RS06775 (1307732) 1307732..1308418 - 687 WP_000141556.1 thermonuclease family protein -
IF703_RS06780 (1308759) 1308759..1309241 - 483 WP_000824492.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174746 WP_000052076.1 NZ_CP062382:1305081-1305269 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174746 NZ_CP081489:c4487228-4487121 [Escherichia coli BL21(DE3)]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174746 WP_001059690.1 NZ_CP062382:1304792-1305052 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174746 NZ_CP081489:4487275-4487341 [Escherichia coli BL21(DE3)]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References