Detailed information of TA system TA174737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2790378..2790916
• Replicon: chromosome
• Accession: NZ_CP062380
• Organism: Staphylococcus aureus strain NAS_AN_076

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: IF704_RS13815
• Protein ID: WP_042907701.1
• Coordinates: 2790590..2790916 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: C5QLS5
• Locus tag: IF704_RS13810
• Protein ID: WP_001058489.1
• Coordinates: 2790378..2790587 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF704_RS13775 (2785624)	2785624..2785908	+	285	WP_031918283.1	co-chaperone GroES	-
IF704_RS13780 (2785984)	2785984..2787600	+	1617	WP_047213652.1	chaperonin GroEL	-
IF704_RS13785 (2787669)	2787669..2788841	-	1173	WP_000179346.1	tyrosine-type recombinase/integrase	-
IF704_RS13790 (2788855)	2788855..2789529	-	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
IF704_RS13795 (2789702)	2789702..2789920	+	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
IF704_RS13800 (2789925)	2789925..2790242	+	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
IF704_RS13805 (2790239)	2790239..2790385	+	147	WP_000784885.1	hypothetical protein	-
IF704_RS13810 (2790378)	2790378..2790587	+	210	WP_001058489.1	hypothetical protein	Antitoxin
IF704_RS13815 (2790590)	2790590..2790916	+	327	WP_042907701.1	DUF1474 family protein	Toxin
IF704_RS13820 (2790982)	2790982..2791851	+	870	WP_064138582.1	primase alpha helix C-terminal domain-containing protein	-
IF704_RS13825 (2791865)	2791865..2793565	+	1701	WP_000447470.1	DUF927 domain-containing protein	-
IF704_RS13830 (2793895)	2793895..2794275	+	381	WP_000356942.1	hypothetical protein	-
IF704_RS13835 (2794272)	2794272..2794913	+	642	WP_001047698.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb	2785624..2833220	47596

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12969.58 Da
• Isoelectric Point: 4.8297

>T174737 WP_042907701.1 NZ_CP062380:2790590-2790916 [Staphylococcus aureus]
MNWEIKNLMCDLKILKEKFEDLKDNHGSHFEDLYIHEPNHTLNKVDVIKEGLSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDAQKLKITE

Nucleotide

• Length: 327 bp

>T174737 NZ_CP081489:c2981465-2981292 [Escherichia coli BL21(DE3)]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8225.24 Da
• Isoelectric Point: 4.2820

>AT174737 WP_001058489.1 NZ_CP062380:2790378-2790587 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT174737 NZ_CP081489:c2981789-2981493 [Escherichia coli BL21(DE3)]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A853V601