174736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2738499..2739028 Replicon chromosome
Accession NZ_CP062380
Organism Staphylococcus aureus strain NAS_AN_076

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF704_RS13545 Protein ID WP_000621175.1
Coordinates 2738666..2739028 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF704_RS13540 Protein ID WP_000948331.1
Coordinates 2738499..2738669 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF704_RS13510 (2733535) 2733535..2734095 + 561 WP_001092403.1 K(+)-transporting ATPase subunit C -
IF704_RS13515 (2734304) 2734304..2734783 + 480 WP_001287075.1 hypothetical protein -
IF704_RS13520 (2734776) 2734776..2736359 + 1584 WP_240022138.1 PH domain-containing protein -
IF704_RS13525 (2736346) 2736346..2736837 + 492 WP_001205919.1 PH domain-containing protein -
IF704_RS13530 (2736841) 2736841..2737200 + 360 WP_000581198.1 holo-ACP synthase -
IF704_RS13535 (2737266) 2737266..2738414 + 1149 WP_001281143.1 alanine racemase -
IF704_RS13540 (2738499) 2738499..2738669 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF704_RS13545 (2738666) 2738666..2739028 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF704_RS13550 (2739378) 2739378..2740379 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF704_RS13555 (2740498) 2740498..2740824 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF704_RS13560 (2740826) 2740826..2741305 + 480 WP_001190825.1 anti-sigma B factor RsbW -
IF704_RS13565 (2741280) 2741280..2742050 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174736 WP_000621175.1 NZ_CP062380:2738666-2739028 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174736 NZ_CP081489:2518442-2518549 [Escherichia coli BL21(DE3)]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174736 WP_000948331.1 NZ_CP062380:2738499-2738669 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174736 NZ_CP081489:c2518395-2518329 [Escherichia coli BL21(DE3)]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References