Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2718770..2719284 Replicon chromosome
Accession NZ_CP062380
Organism Staphylococcus aureus strain NAS_AN_076

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF704_RS13455 Protein ID WP_000581792.1
Coordinates 2719075..2719284 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF704_RS13450 Protein ID WP_000138932.1
Coordinates 2718770..2719063 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF704_RS13430 (2714215) 2714215..2714856 + 642 WP_064138554.1 thiamine phosphate synthase -
IF704_RS13435 (2714942) 2714942..2715814 + 873 WP_000725802.1 membrane protein insertase YidC -
IF704_RS13440 (2716445) 2716445..2717092 - 648 WP_001187620.1 HD domain-containing protein -
IF704_RS13445 (2717120) 2717120..2718604 - 1485 WP_000571551.1 cardiolipin synthase -
IF704_RS13450 (2718770) 2718770..2719063 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF704_RS13455 (2719075) 2719075..2719284 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF704_RS13460 (2719412) 2719412..2719549 + 138 WP_000828354.1 Lmo0850 family protein -
IF704_RS13465 (2719813) 2719813..2721015 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF704_RS13470 (2721333) 2721333..2722403 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF704_RS13475 (2722418) 2722418..2723776 + 1359 WP_047213666.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174735 WP_000581792.1 NZ_CP062380:2719075-2719284 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174735 NZ_CP081489:1783906-1784009 [Escherichia coli BL21(DE3)]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174735 WP_000138932.1 NZ_CP062380:2718770-2719063 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174735 NZ_CP081489:c1784047-1783776 [Escherichia coli BL21(DE3)]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References