Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1264822..1265299 | Replicon | chromosome |
| Accession | NZ_CP062380 | ||
| Organism | Staphylococcus aureus strain NAS_AN_076 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | IF704_RS06450 | Protein ID | WP_000052076.1 |
| Coordinates | 1265111..1265299 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | IF704_RS06445 | Protein ID | WP_001059690.1 |
| Coordinates | 1264822..1265082 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF704_RS06410 (1260378) | 1260378..1260872 | + | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
| IF704_RS06415 (1261087) | 1261087..1262406 | + | 1320 | WP_001807150.1 | ISL3-like element IS1181 family transposase | - |
| IF704_RS06420 (1262409) | 1262409..1262480 | + | 72 | Protein_1240 | hypothetical protein | - |
| IF704_RS06425 (1262549) | 1262549..1263166 | + | 618 | WP_047213256.1 | LysE/ArgO family amino acid transporter | - |
| IF704_RS06430 (1263239) | 1263239..1263820 | - | 582 | WP_001140691.1 | histidine phosphatase family protein | - |
| IF704_RS06435 (1264045) | 1264045..1264281 | + | 237 | WP_000368687.1 | hypothetical protein | - |
| IF704_RS06440 (1264278) | 1264278..1264481 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| IF704_RS06445 (1264822) | 1264822..1265082 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| IF704_RS06450 (1265111) | 1265111..1265299 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| IF704_RS06455 (1265487) | 1265487..1266056 | + | 570 | WP_001106648.1 | lipoprotein N-acylation protein LnsA | - |
| IF704_RS06460 (1266144) | 1266144..1266428 | + | 285 | WP_001004397.1 | hypothetical protein | - |
| IF704_RS06465 (1266490) | 1266490..1266708 | + | 219 | WP_000005883.1 | hypothetical protein | - |
| IF704_RS06470 (1267205) | 1267205..1267405 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| IF704_RS06475 (1267762) | 1267762..1268448 | - | 687 | WP_000141556.1 | thermonuclease family protein | - |
| IF704_RS06480 (1268789) | 1268789..1269271 | - | 483 | WP_000824492.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp | 1260378..1282381 | 22003 | |
| - | flank | IS/Tn | - | - | 1261087..1262406 | 1319 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T174726 WP_000052076.1 NZ_CP062380:1265111-1265299 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T174726 NZ_CP081478:222802-223179 [Pseudomonas aeruginosa]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT174726 WP_001059690.1 NZ_CP062380:1264822-1265082 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT174726 NZ_CP081478:223160-223495 [Pseudomonas aeruginosa]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |