Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 177807..178583 Replicon chromosome
Accession NZ_CP062380
Organism Staphylococcus aureus strain NAS_AN_076

Toxin (Protein)


Gene name tsbT Uniprot ID A0A380DXA2
Locus tag IF704_RS01185 Protein ID WP_000031110.1
Coordinates 178431..178583 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag IF704_RS01180 Protein ID WP_001251219.1
Coordinates 177807..178406 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF704_RS01160 (173723) 173723..175180 + 1458 WP_031927464.1 ABC transporter permease subunit -
IF704_RS01165 (175173) 175173..175895 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
IF704_RS01170 (176046) 176046..177173 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
IF704_RS01175 (177178) 177178..177648 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
IF704_RS01180 (177807) 177807..178406 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
IF704_RS01185 (178431) 178431..178583 + 153 WP_000031110.1 SAS053 family protein Toxin
IF704_RS01190 (179243) 179243..179638 + 396 WP_000901023.1 hypothetical protein -
IF704_RS01195 (179834) 179834..181219 + 1386 WP_000116225.1 class II fumarate hydratase -
IF704_RS01200 (181669) 181669..182490 - 822 WP_000669377.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5964.34 Da        Isoelectric Point: 3.9953

>T174725 WP_000031110.1 NZ_CP062380:178431-178583 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMERISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T174725 NZ_CP081477:c6411557-6411276 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT174725 WP_001251219.1 NZ_CP062380:177807-178406 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT174725 NZ_CP081477:c6411781-6411554 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380DXA2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References