Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2158654..2159177 Replicon chromosome
Accession NZ_CP062378
Organism Staphylococcus aureus strain NAS_AN_079

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag IF705_RS10945 Protein ID WP_000074049.1
Coordinates 2158654..2158920 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF705_RS10950 Protein ID WP_000587616.1
Coordinates 2158920..2159177 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF705_RS10925 (2153961) 2153961..2155148 - 1188 WP_000026189.1 MFS transporter -
IF705_RS10930 (2155544) 2155544..2156320 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
IF705_RS10935 (2156313) 2156313..2156975 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
IF705_RS10940 (2157223) 2157223..2158299 - 1077 WP_001076673.1 M42 family metallopeptidase -
IF705_RS10945 (2158654) 2158654..2158920 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
IF705_RS10950 (2158920) 2158920..2159177 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF705_RS10955 (2159536) 2159536..2159991 + 456 WP_000732076.1 DUF1307 domain-containing protein -
IF705_RS10960 (2160159) 2160159..2161736 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
IF705_RS10965 (2161931) 2161931..2162680 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T174718 WP_000074049.1 NZ_CP062378:c2158920-2158654 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174718 NZ_CP081477:c2843347-2843093 [Pseudomonas aeruginosa]
GTGAAGCTGATCTGGTCGGAACAAGCCTGGGACGATTATCTGTACTGGCAGGACACGGATAAGCGTATGGTGAAAAAGGT
CAACGAGTTGATCAAGGATGCCTGCCGTACCCCGTTCGAGGGCAAGGGCAAGCCGGAGCCGCTTCGCCACAACCTGGCGG
GCTTCTGGTCGAGACGGATCACGGCCGAGCATCGGTTTGTGTATTCGGTGACGGATGACGCGCTGCTGATTGCAGCCTGC
CGTTACCACTATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174718 WP_000587616.1 NZ_CP062378:c2159177-2158920 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174718 NZ_CP081477:c2843595-2843344 [Pseudomonas aeruginosa]
ATGCGCACGATCAGTTACACCGAAGCCCGGCAGAACCTGTCGGCCACCATGATGAAGACCGTGGAGGATCGCGCCCCGAT
CCTGATTACCCGGCAGAACGGCGAAGCCTGCGTGTTGATGTCCCTGGAAGAGTTCAACGCGCTGGAGGAAACGGCTTATC
TGCTGCGCTCCCCGGCCAATGCCCGCCGCCTGATGGATTCGATTGACAGCCTCAAGCAAGGCCAGGGCGTCGAGCGGGAT
TTGGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References