Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1784938..1785452 Replicon chromosome
Accession NZ_CP062378
Organism Staphylococcus aureus strain NAS_AN_079

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF705_RS08995 Protein ID WP_000581792.1
Coordinates 1784938..1785147 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF705_RS09000 Protein ID WP_000138932.1
Coordinates 1785159..1785452 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF705_RS08975 (1780447) 1780447..1781805 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IF705_RS08980 (1781820) 1781820..1782890 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF705_RS08985 (1783208) 1783208..1784410 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF705_RS08990 (1784674) 1784674..1784810 - 137 Protein_1729 Lmo0850 family protein -
IF705_RS08995 (1784938) 1784938..1785147 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF705_RS09000 (1785159) 1785159..1785452 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF705_RS09005 (1785618) 1785618..1787102 + 1485 WP_000571549.1 cardiolipin synthase -
IF705_RS09010 (1787130) 1787130..1787777 + 648 WP_001187630.1 HD domain-containing protein -
IF705_RS09015 (1788690) 1788690..1789562 - 873 WP_000725802.1 membrane protein insertase YidC -
IF705_RS09020 (1789648) 1789648..1790289 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174712 WP_000581792.1 NZ_CP062378:c1785147-1784938 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174712 NZ_CP081457:4669345-4669626 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
ATGAGAGAGTTGAAGGTTTTCGAAGCTTCTGACTACCTGAACAACGACGAGGAAATTGCCGAGTTTCTGAGCATTTCCCT
GGAAGATCCAAACCCTGACGTTTTCCTCAGGGCTTTGCAGGAAGTCGCGAAGGCGCGTGGAATGAGCCAGCTTGCCCGTG
ACGCTGGCATCAATCGCGAATCGCTCTACAAAGCTTTGACACCAGGTGCAAAGCCTCGGTATGACACGGTTTTGAAGGTG
ATGAATGCGTTAGGCATGAAGCTGACCGCTCAGCACGTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174712 WP_000138932.1 NZ_CP062378:c1785452-1785159 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174712 NZ_CP081457:4669040-4669348 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
ATGAACACACTCATCAGAACCCACGAATTCGACGCATGGCTGAAAGGCTTGAGGGACGTAACAGCGCGCCTGAGAATCCT
GAACCGTATCATGGCGGCACAGGAAGGCAACTTTGGTGACTGTGAGCCAGTCGGGCACGGCATCAGTGAAATGCGCATCT
TCGTAGGACCTGGCTACCGTGTGTACTACACCAGGCGCGCAGAAGTGGTCTATCTGCTACTGTGTGGCGGCAACAAGTCC
TCACAGAAGCGCGACATAAAGCTGGCGAAATCCATCCTCGATGAGATCGAGAAAGGAGACGTAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References