Detailed information of TA system TA174710

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1610465..1611241
• Replicon: chromosome
• Accession: NZ_CP062378
• Organism: Staphylococcus aureus strain NAS_AN_079

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: IF705_RS08015
• Protein ID: WP_000031108.1
• Coordinates: 1610465..1610617 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: IF705_RS08020
• Protein ID: WP_001251224.1
• Coordinates: 1610642..1611241 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF705_RS08000 (1606667)	1606667..1607488	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
IF705_RS08005 (1607941)	1607941..1609326	-	1386	WP_000116228.1	class II fumarate hydratase	-
IF705_RS08010 (1609522)	1609522..1609917	-	396	WP_000901023.1	hypothetical protein	-
IF705_RS08015 (1610465)	1610465..1610617	-	153	WP_000031108.1	SAS053 family protein	Toxin
IF705_RS08020 (1610642)	1610642..1611241	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
IF705_RS08025 (1611400)	1611400..1611870	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
IF705_RS08030 (1611875)	1611875..1613002	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
IF705_RS08035 (1613153)	1613153..1613875	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
IF705_RS08040 (1613868)	1613868..1615325	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T174710 WP_000031108.1 NZ_CP062378:c1610617-1610465 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T174710 NZ_CP081457:c4495670-4495368 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
ATGATCGAAATTAAACAGACAGCTATTTTCATGGCGTGGGAAAGAAAGCTGCAGGACGACAGGGCAAGGGCGGCTATCGC
AGCGCGATTATTTCGCCTGGCTAACGGGCTTGCAGGAGACGTTCGTCCGGTGGGCCGAGGTGTCAGTGAGCTACGTGTTC
ATTACGGTCCTGGCTACCGGATTTACTTTCAACAGCGCGGCAGTGAACTGGTCATTTTGCTGTGTGGCGGCAACAAGGGC
AGTCAAAGCCGTGACATTGAGAAAGCCAAAGAACTTGCATGCAACTGGAGTCCACATGACTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT174710 WP_001251224.1 NZ_CP062378:c1611241-1610642 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT174710 NZ_CP081457:c4495375-4495082 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
ATGACTGAACAACTTTATGCTTATGATCCAGCCGAAGCGCTGACATCTCCTGAGGCAATCGCCGAATTCATGACCGACGC
GTTCGCGAGCGGCGATGTTGGCTACATTGCCAAGGCCTTGGGCGTGGTTGCGCGCGCACGCGGCATGACAGACATGGCTC
GCGAGACCGGGCTGTCTCGTGAGCAGCTCTATCGCTCGTTCAGTGAGGAGGGGAATCCGACACTGAAGACGCTGCTTGCA
GTGATGCAAGTCATCGGCCTGGACATCACCGCCCAGCCTCGCGCTGCCACGTAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4