Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 531341..531818 Replicon chromosome
Accession NZ_CP062378
Organism Staphylococcus aureus strain NAS_AN_079

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF705_RS02695 Protein ID WP_000052076.1
Coordinates 531341..531529 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF705_RS02700 Protein ID WP_001059690.1
Coordinates 531558..531818 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF705_RS02665 (527335) 527335..527856 + 522 WP_000824482.1 hypothetical protein -
IF705_RS02670 (528197) 528197..528883 + 687 WP_000141557.1 thermonuclease family protein -
IF705_RS02675 (529240) 529240..529440 + 201 WP_001059082.1 cold-shock protein -
IF705_RS02680 (529932) 529932..530150 - 219 WP_000005886.1 hypothetical protein -
IF705_RS02685 (530212) 530212..530496 - 285 WP_001004399.1 hypothetical protein -
IF705_RS02690 (530584) 530584..531153 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
IF705_RS02695 (531341) 531341..531529 - 189 WP_000052076.1 hypothetical protein Toxin
IF705_RS02700 (531558) 531558..531818 - 261 WP_001059690.1 hypothetical protein Antitoxin
IF705_RS02705 (532159) 532159..532362 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IF705_RS02710 (532359) 532359..532595 - 237 WP_000349581.1 hypothetical protein -
IF705_RS02715 (532820) 532820..533401 + 582 WP_001140693.1 histidine phosphatase family protein -
IF705_RS02720 (533474) 533474..534091 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
IF705_RS02725 (534246) 534246..534740 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF705_RS02730 (535139) 535139..535561 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
IF705_RS02735 (535709) 535709..536425 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174707 WP_000052076.1 NZ_CP062378:c531529-531341 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174707 NZ_CP081457:c2099583-2099299 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
ATGCAGGTTGAATGGCTAAAAACAGCATTAAAAAACCTGGATGATGAAGCCGCCTACATCTCGCTAGAAAATCCGGCTGC
TGCGGTTGCTTTCGTAGAAGCGATACAAATAAGCGTAAAGCAGCTCGCAAGCTTTCCGGCCCTAGGCCGAGAGGGACGAA
TTGCTGGCACCAGAGAATGGCCTTTGCCAGACTGGCCTTACCTGATTCCATACCGCATCCGTAACGGCCGATTACAGGTT
CTGCGGATTTTCCACACGAGAAGGCAGCCGCCGTTGGTGTGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174707 WP_001059690.1 NZ_CP062378:c531818-531558 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174707 NZ_CP081457:c2099812-2099573 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
ATGTCCGTTATGTCTCTACGCCTGCCGGACGAGATGGCAGATACCCTTGCACACCTCGCCAAAGCGACCGGCCGCAGCAA
GTCGTTTTTGGCCCTGAACGCATTACGTGAATACTTGACTCGCGAAGCCTGGCAGATTGCCGAAATTCAGCGTGCAATTG
AAGAAGCAGACGCGGGCGAGTTCGCAAGTGAAGAAGATGTAAAGGCAGTGATGAATAAATGGGCGAACAATGCAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References