Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2659212..2659741 Replicon chromosome
Accession NZ_CP062376
Organism Staphylococcus aureus strain NAS_AN_099

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF707_RS13015 Protein ID WP_000621175.1
Coordinates 2659379..2659741 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF707_RS13010 Protein ID WP_000948331.1
Coordinates 2659212..2659382 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF707_RS12980 (2654248) 2654248..2654808 + 561 WP_001092409.1 K(+)-transporting ATPase subunit C -
IF707_RS12985 (2655017) 2655017..2655496 + 480 WP_001287079.1 hypothetical protein -
IF707_RS12990 (2655489) 2655489..2657072 + 1584 WP_045177766.1 PH domain-containing protein -
IF707_RS12995 (2657059) 2657059..2657550 + 492 WP_072353916.1 PH domain-containing protein -
IF707_RS13000 (2657554) 2657554..2657913 + 360 WP_000581197.1 holo-ACP synthase -
IF707_RS13005 (2657979) 2657979..2659127 + 1149 WP_001281154.1 alanine racemase -
IF707_RS13010 (2659212) 2659212..2659382 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF707_RS13015 (2659379) 2659379..2659741 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF707_RS13020 (2660091) 2660091..2661092 + 1002 WP_240017422.1 PP2C family protein-serine/threonine phosphatase -
IF707_RS13025 (2661211) 2661211..2661537 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF707_RS13030 (2661539) 2661539..2662018 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IF707_RS13035 (2661993) 2661993..2662763 + 771 WP_001041102.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174702 WP_000621175.1 NZ_CP062376:2659379-2659741 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174702 NZ_CP081354:c2559137-2559030 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174702 WP_000948331.1 NZ_CP062376:2659212-2659382 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174702 NZ_CP081354:2558953-2559013 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References