Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2639469..2639983 Replicon chromosome
Accession NZ_CP062376
Organism Staphylococcus aureus strain NAS_AN_099

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF707_RS12925 Protein ID WP_000581792.1
Coordinates 2639774..2639983 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF707_RS12920 Protein ID WP_000138932.1
Coordinates 2639469..2639762 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF707_RS12900 (2635079) 2635079..2635720 + 642 WP_000483164.1 thiamine phosphate synthase -
IF707_RS12905 (2635806) 2635806..2636678 + 873 WP_000725802.1 membrane protein insertase YidC -
IF707_RS12910 (2637144) 2637144..2637791 - 648 WP_001187630.1 HD domain-containing protein -
IF707_RS12915 (2637819) 2637819..2639303 - 1485 WP_000571549.1 cardiolipin synthase -
IF707_RS12920 (2639469) 2639469..2639762 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF707_RS12925 (2639774) 2639774..2639983 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF707_RS12930 (2640111) 2640111..2640248 + 138 WP_000828354.1 Lmo0850 family protein -
IF707_RS12935 (2640512) 2640512..2641714 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF707_RS12940 (2642032) 2642032..2643102 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF707_RS12945 (2643117) 2643117..2644475 + 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174701 WP_000581792.1 NZ_CP062376:2639774-2639983 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174701 NZ_CP081354:c2533871-2533605 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174701 WP_000138932.1 NZ_CP062376:2639469-2639762 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174701 NZ_CP081354:c2534122-2533871 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References