Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1167126..1167603 Replicon chromosome
Accession NZ_CP062376
Organism Staphylococcus aureus strain NAS_AN_099

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IF707_RS05790 Protein ID WP_000052076.1
Coordinates 1167415..1167603 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IF707_RS05785 Protein ID WP_001059690.1
Coordinates 1167126..1167386 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF707_RS05750 (1162519) 1162519..1163235 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
IF707_RS05755 (1163383) 1163383..1163805 + 423 WP_240017449.1 organic hydroperoxide resistance protein -
IF707_RS05760 (1164204) 1164204..1164698 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
IF707_RS05765 (1164853) 1164853..1165470 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
IF707_RS05770 (1165543) 1165543..1166124 - 582 WP_001140697.1 histidine phosphatase family protein -
IF707_RS05775 (1166349) 1166349..1166585 + 237 WP_000368687.1 hypothetical protein -
IF707_RS05780 (1166582) 1166582..1166785 - 204 WP_050969965.1 sterile alpha motif-like domain-containing protein -
IF707_RS05785 (1167126) 1167126..1167386 + 261 WP_001059690.1 hypothetical protein Antitoxin
IF707_RS05790 (1167415) 1167415..1167603 + 189 WP_000052076.1 hypothetical protein Toxin
IF707_RS05795 (1167791) 1167791..1168360 + 570 WP_045178121.1 lipoprotein N-acylation protein LnsA -
IF707_RS05800 (1168448) 1168448..1168732 + 285 WP_001004401.1 hypothetical protein -
IF707_RS05805 (1168794) 1168794..1169012 + 219 WP_000005886.1 hypothetical protein -
IF707_RS05810 (1169508) 1169508..1169708 - 201 WP_001059082.1 cold-shock protein -
IF707_RS05815 (1170065) 1170065..1170751 - 687 WP_001566557.1 thermonuclease family protein -
IF707_RS05820 (1171092) 1171092..1171562 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T174692 WP_000052076.1 NZ_CP062376:1167415-1167603 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T174692 NZ_CP081351:c4767727-4767470 [Klebsiella michiganensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT174692 WP_001059690.1 NZ_CP062376:1167126-1167386 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT174692 NZ_CP081351:c4767459-4766908 [Klebsiella michiganensis]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTGCTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References