Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2041364..2041878 Replicon chromosome
Accession NZ_CP062372
Organism Staphylococcus aureus strain NAS_AN_109

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF710_RS09950 Protein ID WP_000581792.1
Coordinates 2041364..2041573 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF710_RS09955 Protein ID WP_000138932.1
Coordinates 2041585..2041878 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF710_RS09930 (IF710_09900) 2036872..2038230 - 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IF710_RS09935 (IF710_09905) 2038245..2039315 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF710_RS09940 (IF710_09910) 2039633..2040835 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF710_RS09945 (IF710_09915) 2041099..2041236 - 138 WP_000828354.1 Lmo0850 family protein -
IF710_RS09950 (IF710_09920) 2041364..2041573 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF710_RS09955 (IF710_09925) 2041585..2041878 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF710_RS09960 (IF710_09930) 2042044..2043528 + 1485 WP_000571549.1 cardiolipin synthase -
IF710_RS09965 (IF710_09935) 2043556..2044203 + 648 WP_001187630.1 HD domain-containing protein -
IF710_RS09970 (IF710_09940) 2044675..2045547 - 873 WP_000725802.1 membrane protein insertase YidC -
IF710_RS09975 (IF710_09945) 2045633..2046274 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174682 WP_000581792.1 NZ_CP062372:c2041573-2041364 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174682 NZ_CP081346:c5121690-5121343 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174682 WP_000138932.1 NZ_CP062372:c2041878-2041585 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174682 NZ_CP081346:c5121951-5121700 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACTTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References