Detailed information of TA system TA174677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 827168..827645
• Replicon: chromosome
• Accession: NZ_CP062372
• Organism: Staphylococcus aureus strain NAS_AN_109

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IF710_RS03970
• Protein ID: WP_000052076.1
• Coordinates: 827168..827356 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IF710_RS03975
• Protein ID: WP_001059690.1
• Coordinates: 827385..827645 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF710_RS03940 (IF710_03915)	823158..823679	+	522	WP_000824484.1	hypothetical protein	-
IF710_RS03945 (IF710_03920)	824020..824706	+	687	WP_001792695.1	thermonuclease family protein	-
IF710_RS03950 (IF710_03925)	825063..825263	+	201	WP_001059082.1	cold-shock protein	-
IF710_RS03955 (IF710_03930)	825759..825977	-	219	WP_000005886.1	hypothetical protein	-
IF710_RS03960 (IF710_03935)	826039..826323	-	285	WP_001004395.1	hypothetical protein	-
IF710_RS03965 (IF710_03940)	826411..826980	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
IF710_RS03970 (IF710_03945)	827168..827356	-	189	WP_000052076.1	hypothetical protein	Toxin
IF710_RS03975 (IF710_03950)	827385..827645	-	261	WP_001059690.1	hypothetical protein	Antitoxin
IF710_RS03980 (IF710_03955)	827986..828189	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IF710_RS03985 (IF710_03960)	828186..828422	-	237	WP_000368687.1	hypothetical protein	-
IF710_RS03990 (IF710_03965)	828647..829228	+	582	WP_001140693.1	histidine phosphatase family protein	-
IF710_RS03995 (IF710_03970)	829301..829918	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
IF710_RS04000 (IF710_03975)	830073..830567	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
IF710_RS04005 (IF710_03980)	830966..831388	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IF710_RS04010 (IF710_03985)	831536..832252	+	717	WP_000150012.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T174677 WP_000052076.1 NZ_CP062372:c827356-827168 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T174677 NZ_CP081346:c150371-150090 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT174677 WP_001059690.1 NZ_CP062372:c827645-827385 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT174677 NZ_CP081346:c150595-150368 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56