Detailed information of TA system TA174676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 800982..801511
• Replicon: chromosome
• Accession: NZ_CP062372
• Organism: Staphylococcus aureus strain NAS_AN_109

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: IF710_RS03820
• Protein ID: WP_001103939.1
• Coordinates: 801194..801511 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: IF710_RS03815
• Protein ID: WP_001058492.1
• Coordinates: 800982..801191 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF710_RS03780 (IF710_03760)	797312..797776	+	465	WP_001085185.1	SsrA-binding protein SmpB	-
IF710_RS03790 (IF710_03770)	798339..799445	-	1107	WP_000149511.1	tyrosine-type recombinase/integrase	-
IF710_RS03795 (IF710_03775)	799435..800238	-	804	WP_000358990.1	helix-turn-helix transcriptional regulator	-
IF710_RS03800 (IF710_03780)	800374..800577	+	204	WP_001045296.1	transcriptional regulator	-
IF710_RS03805 (IF710_03785)	800613..800831	+	219	WP_000163544.1	helix-turn-helix transcriptional regulator	-
IF710_RS03810 (IF710_03790)	800843..800989	+	147	WP_000784885.1	hypothetical protein	-
IF710_RS03815 (IF710_03795)	800982..801191	+	210	WP_001058492.1	hypothetical protein	Antitoxin
IF710_RS03820 (IF710_03800)	801194..801511	+	318	WP_001103939.1	DUF1474 family protein	Toxin
IF710_RS03825 (IF710_03805)	801575..802444	+	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
IF710_RS03830 (IF710_03810)	802461..803918	+	1458	WP_000390453.1	virulence-associated E family protein	-
IF710_RS03835 (IF710_03815)	804219..804581	+	363	WP_001039170.1	hypothetical protein	-
IF710_RS03840 (IF710_03820)	804583..804867	+	285	WP_000998185.1	hypothetical protein	-
IF710_RS03845 (IF710_03825)	804864..805505	+	642	WP_001019807.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sec / sell / sell	798339..816561	18222

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T174676 WP_001103939.1 NZ_CP062372:801194-801511 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T174676 NZ_CP081345:c5851510-5851232 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT174676 WP_001058492.1 NZ_CP062372:800982-801191 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT174676 NZ_CP081345:c5851220-5850915 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IA75