Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2262035..2262558 Replicon chromosome
Accession NZ_CP062370
Organism Staphylococcus aureus strain NAS_AN_111

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag IF711_RS11040 Protein ID WP_000074049.1
Coordinates 2262292..2262558 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF711_RS11035 Protein ID WP_000587616.1
Coordinates 2262035..2262292 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF711_RS11020 (2258532) 2258532..2259281 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
IF711_RS11025 (2259476) 2259476..2261053 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
IF711_RS11030 (2261221) 2261221..2261676 - 456 WP_000732076.1 DUF1307 domain-containing protein -
IF711_RS11035 (2262035) 2262035..2262292 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF711_RS11040 (2262292) 2262292..2262558 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
IF711_RS11045 (2262913) 2262913..2263989 + 1077 WP_001076673.1 M42 family metallopeptidase -
IF711_RS11050 (2264237) 2264237..2264899 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
IF711_RS11055 (2264892) 2264892..2265668 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
IF711_RS11060 (2266064) 2266064..2267251 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T174666 WP_000074049.1 NZ_CP062370:2262292-2262558 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174666 NZ_CP081342:2059975-2060072 [Pantoea ananatis]
GCAAGGCGAAAGCCTCTATCAATGCCAACTTTTAGCGCACGGCTCCTTGAGAGCCATTTCCCTGGACCGAATACAGGAAT
CGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174666 WP_000587616.1 NZ_CP062370:2262035-2262292 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174666 NZ_CP081342:c2060072-2059940 [Pantoea ananatis]
AAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTCAAGGAGCCGTGCGCTAAAAGTTGGCATTGA
TAGAGGCTTTCGCCTTGCTTTTAAAGCGTAGGACAACGCGCCAGATTTTCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References