Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2844549..2845078 Replicon chromosome
Accession NZ_CP062366
Organism Staphylococcus aureus strain NAS_AN_123

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IF713_RS14330 Protein ID WP_000621175.1
Coordinates 2844716..2845078 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag IF713_RS14325 Protein ID WP_000948331.1
Coordinates 2844549..2844719 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF713_RS14295 (2839586) 2839586..2840146 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
IF713_RS14300 (2840354) 2840354..2840833 + 480 WP_001287088.1 hypothetical protein -
IF713_RS14305 (2840826) 2840826..2842409 + 1584 WP_001294626.1 PH domain-containing protein -
IF713_RS14310 (2842396) 2842396..2842887 + 492 WP_001205910.1 PH domain-containing protein -
IF713_RS14315 (2842891) 2842891..2843250 + 360 WP_000581200.1 holo-ACP synthase -
IF713_RS14320 (2843316) 2843316..2844464 + 1149 WP_001281145.1 alanine racemase -
IF713_RS14325 (2844549) 2844549..2844719 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IF713_RS14330 (2844716) 2844716..2845078 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IF713_RS14335 (2845427) 2845427..2846428 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
IF713_RS14340 (2846547) 2846547..2846873 + 327 WP_001052491.1 anti-sigma factor antagonist -
IF713_RS14345 (2846875) 2846875..2847354 + 480 WP_001190829.1 anti-sigma B factor RsbW -
IF713_RS14350 (2847329) 2847329..2848099 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T174641 WP_000621175.1 NZ_CP062366:2844716-2845078 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T174641 NZ_CP081306:2677153-2677260 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT174641 WP_000948331.1 NZ_CP062366:2844549-2844719 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT174641 NZ_CP081306:c2677100-2677039 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References