Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2824808..2825322 Replicon chromosome
Accession NZ_CP062366
Organism Staphylococcus aureus strain NAS_AN_123

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF713_RS14240 Protein ID WP_000581792.1
Coordinates 2825113..2825322 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF713_RS14235 Protein ID WP_000138932.1
Coordinates 2824808..2825101 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF713_RS14215 (2820071) 2820071..2820712 + 642 WP_000483153.1 thiamine phosphate synthase -
IF713_RS14220 (2820798) 2820798..2821670 + 873 WP_000725802.1 membrane protein insertase YidC -
IF713_RS14225 (2822483) 2822483..2823130 - 648 WP_001187629.1 HD domain-containing protein -
IF713_RS14230 (2823158) 2823158..2824642 - 1485 WP_000571549.1 cardiolipin synthase -
IF713_RS14235 (2824808) 2824808..2825101 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF713_RS14240 (2825113) 2825113..2825322 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF713_RS14245 (2825450) 2825450..2825587 + 138 WP_000828354.1 Lmo0850 family protein -
IF713_RS14250 (2825851) 2825851..2827053 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF713_RS14255 (2827371) 2827371..2828441 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF713_RS14260 (2828456) 2828456..2829814 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174640 WP_000581792.1 NZ_CP062366:2825113-2825322 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174640 NZ_CP081306:2676617-2676724 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174640 WP_000138932.1 NZ_CP062366:2824808-2825101 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174640 NZ_CP081306:c2676570-2676504 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References