Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1272001..1272478 | Replicon | chromosome |
| Accession | NZ_CP062366 | ||
| Organism | Staphylococcus aureus strain NAS_AN_123 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q2G005 |
| Locus tag | IF713_RS06600 | Protein ID | WP_000052078.1 |
| Coordinates | 1272290..1272478 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | IF713_RS06595 | Protein ID | WP_001059690.1 |
| Coordinates | 1272001..1272261 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF713_RS06560 (1267394) | 1267394..1268110 | - | 717 | WP_000150017.1 | type I 3-dehydroquinate dehydratase | - |
| IF713_RS06565 (1268258) | 1268258..1268680 | + | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| IF713_RS06570 (1269079) | 1269079..1269573 | + | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| IF713_RS06575 (1269728) | 1269728..1270345 | + | 618 | WP_000255561.1 | LysE/ArgO family amino acid transporter | - |
| IF713_RS06580 (1270418) | 1270418..1270999 | - | 582 | WP_001140686.1 | histidine phosphatase family protein | - |
| IF713_RS06585 (1271224) | 1271224..1271460 | + | 237 | WP_000368687.1 | hypothetical protein | - |
| IF713_RS06590 (1271457) | 1271457..1271660 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| IF713_RS06595 (1272001) | 1272001..1272261 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| IF713_RS06600 (1272290) | 1272290..1272478 | + | 189 | WP_000052078.1 | hypothetical protein | Toxin |
| IF713_RS06605 (1272666) | 1272666..1273235 | + | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| IF713_RS06610 (1273323) | 1273323..1273607 | + | 285 | WP_001004395.1 | hypothetical protein | - |
| IF713_RS06615 (1273669) | 1273669..1273887 | + | 219 | WP_000005886.1 | hypothetical protein | - |
| IF713_RS06620 (1274383) | 1274383..1274583 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| IF713_RS06625 (1274940) | 1274940..1275626 | - | 687 | WP_001548082.1 | thermonuclease family protein | - |
| IF713_RS06630 (1275967) | 1275967..1276437 | - | 471 | WP_000824472.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selq / selk / vWbp | 1246712..1279671 | 32959 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7172.84 Da Isoelectric Point: 9.9971
>T174631 WP_000052078.1 NZ_CP062366:1272290-1272478 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T174631 NZ_CP081306:769707-770003 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT174631 WP_001059690.1 NZ_CP062366:1272001-1272261 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT174631 NZ_CP081306:770005-770400 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D6HZ40 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |