Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 2036940..2037454 Replicon chromosome
Accession NZ_CP062364
Organism Staphylococcus aureus strain NAS_AN_130

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF714_RS09835 Protein ID WP_000581792.1
Coordinates 2036940..2037149 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag IF714_RS09840 Protein ID WP_000138934.1
Coordinates 2037161..2037454 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF714_RS09815 (IF714_09785) 2032448..2033806 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IF714_RS09820 (IF714_09790) 2033821..2034891 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
IF714_RS09825 (IF714_09795) 2035209..2036411 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF714_RS09830 (IF714_09800) 2036675..2036812 - 138 WP_000828354.1 Lmo0850 family protein -
IF714_RS09835 (IF714_09805) 2036940..2037149 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF714_RS09840 (IF714_09810) 2037161..2037454 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF714_RS09845 (IF714_09815) 2037620..2039104 + 1485 WP_000571549.1 cardiolipin synthase -
IF714_RS09850 (IF714_09820) 2039132..2039779 + 648 WP_001187610.1 HD domain-containing protein -
IF714_RS09855 (IF714_09825) 2040594..2041466 - 873 WP_000725802.1 membrane protein insertase YidC -
IF714_RS09860 (IF714_09830) 2041552..2042193 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174621 WP_000581792.1 NZ_CP062364:c2037149-2036940 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174621 NZ_CP081287:c4640355-4639600 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT174621 WP_000138934.1 NZ_CP062364:c2037454-2037161 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174621 NZ_CP081287:c4640858-4640490 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6FF1


Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References