Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 818745..819222 | Replicon | chromosome |
| Accession | NZ_CP062364 | ||
| Organism | Staphylococcus aureus strain NAS_AN_130 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | IF714_RS03820 | Protein ID | WP_000052076.1 |
| Coordinates | 818745..818933 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | IF714_RS03825 | Protein ID | WP_001059690.1 |
| Coordinates | 818962..819222 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF714_RS03790 (IF714_03790) | 814783..815253 | + | 471 | WP_000824462.1 | hypothetical protein | - |
| IF714_RS03795 (IF714_03795) | 815594..816280 | + | 687 | WP_001823812.1 | thermonuclease family protein | - |
| IF714_RS03800 (IF714_03800) | 816637..816837 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| IF714_RS03805 (IF714_03805) | 817336..817554 | - | 219 | WP_000005888.1 | hypothetical protein | - |
| IF714_RS03810 (IF714_03810) | 817616..817900 | - | 285 | WP_001004397.1 | hypothetical protein | - |
| IF714_RS03815 (IF714_03815) | 817988..818557 | - | 570 | WP_001106657.1 | lipoprotein N-acylation protein LnsA | - |
| IF714_RS03820 (IF714_03820) | 818745..818933 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| IF714_RS03825 (IF714_03825) | 818962..819222 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| IF714_RS03830 (IF714_03830) | 819563..819766 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| IF714_RS03835 (IF714_03835) | 819763..819999 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| IF714_RS03840 (IF714_03840) | 820224..820805 | + | 582 | WP_001140697.1 | histidine phosphatase family protein | - |
| IF714_RS03845 (IF714_03845) | 820878..821495 | - | 618 | WP_000255554.1 | LysE/ArgO family amino acid transporter | - |
| IF714_RS03850 (IF714_03850) | 821651..822145 | - | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
| IF714_RS03855 (IF714_03855) | 822544..822966 | - | 423 | WP_000974455.1 | organic hydroperoxide resistance protein | - |
| IF714_RS03860 (IF714_03860) | 823114..823830 | + | 717 | WP_000150029.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp / selk / selq / seb | 801138..846502 | 45364 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T174617 WP_000052076.1 NZ_CP062364:c818933-818745 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T174617 NZ_CP081258:139510-140028 [Phaeobacter inhibens]
ATGACCGGCGATAGCGTGCCCGCCCAAGCGCCCCTTGTCGTAAACGGATGGTCGATTTATGCGCATCCGCTCTTTCTGGA
CCAGCTCGAAGGGCTGATCGAGGAAGTCGAGGCGCGTAAGGCACGCGATCCAAAGACCTGGCGCAAGAAAAACCCGACGA
AACGGCTGGCCGCCATCTTCAAGCTGGTCACCGAGGCCATACCGGCAGATCCGGGTGCCGCTGCCTTCCGGCAAGGCGGC
ACACTCGGCGATCACCGCAAGCACTGGTTCCGGGCGAAATTCTTCCAGCAGTATCGGTTGTTCTACCGGTTCAACAGCGA
TGCGAAGGTCATCGTGGTGGCCTGGGTGAACGACGACAAGACTCTGCGCGCCTATGGCAGCAAGACGGATGCCTATGCGA
CCTTCAAAGGGATGCTGGACAATGGCAACCCACCTGACAATTTCGACGTGCTTTTGAAAGAAGCTGCGGCGGCGCACGAG
GGGTTCGAAATGTCCCTTGAAGCGGTGCCTGATCGGTAA
ATGACCGGCGATAGCGTGCCCGCCCAAGCGCCCCTTGTCGTAAACGGATGGTCGATTTATGCGCATCCGCTCTTTCTGGA
CCAGCTCGAAGGGCTGATCGAGGAAGTCGAGGCGCGTAAGGCACGCGATCCAAAGACCTGGCGCAAGAAAAACCCGACGA
AACGGCTGGCCGCCATCTTCAAGCTGGTCACCGAGGCCATACCGGCAGATCCGGGTGCCGCTGCCTTCCGGCAAGGCGGC
ACACTCGGCGATCACCGCAAGCACTGGTTCCGGGCGAAATTCTTCCAGCAGTATCGGTTGTTCTACCGGTTCAACAGCGA
TGCGAAGGTCATCGTGGTGGCCTGGGTGAACGACGACAAGACTCTGCGCGCCTATGGCAGCAAGACGGATGCCTATGCGA
CCTTCAAAGGGATGCTGGACAATGGCAACCCACCTGACAATTTCGACGTGCTTTTGAAAGAAGCTGCGGCGGCGCACGAG
GGGTTCGAAATGTCCCTTGAAGCGGTGCCTGATCGGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT174617 WP_001059690.1 NZ_CP062364:c819222-818962 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT174617 NZ_CP081258:140175-140327 [Phaeobacter inhibens]
GTGGCGGCTGATGTCAATTCGTATGACGCGTGGTTTCGCGCGCAGTTACAGGCCGCGCTTGACGATGCGCGCGCTGGAAC
TTCACAGGTTCAGGTAATGCAGGCCGCGCAGGCTTTGATTGATGCGAAACGCCAGGGCCAATCCAAGCCCTGA
GTGGCGGCTGATGTCAATTCGTATGACGCGTGGTTTCGCGCGCAGTTACAGGCCGCGCTTGACGATGCGCGCGCTGGAAC
TTCACAGGTTCAGGTAATGCAGGCCGCGCAGGCTTTGATTGATGCGAAACGCCAGGGCCAATCCAAGCCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |