174615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2638969..2639483 Replicon chromosome
Accession NZ_CP062362
Organism Staphylococcus aureus strain NAS_AN_152

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IF721_RS13000 Protein ID WP_000581792.1
Coordinates 2639274..2639483 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IF721_RS12995 Protein ID WP_000138932.1
Coordinates 2638969..2639262 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF721_RS12975 (2634573) 2634573..2635214 + 642 WP_000483153.1 thiamine phosphate synthase -
IF721_RS12980 (2635300) 2635300..2636172 + 873 WP_000725802.1 membrane protein insertase YidC -
IF721_RS12985 (2636644) 2636644..2637291 - 648 WP_001187630.1 HD domain-containing protein -
IF721_RS12990 (2637319) 2637319..2638803 - 1485 WP_000571549.1 cardiolipin synthase -
IF721_RS12995 (2638969) 2638969..2639262 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IF721_RS13000 (2639274) 2639274..2639483 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IF721_RS13005 (2639611) 2639611..2639748 + 138 WP_000828354.1 Lmo0850 family protein -
IF721_RS13010 (2640012) 2640012..2641214 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IF721_RS13015 (2641532) 2641532..2642602 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IF721_RS13020 (2642617) 2642617..2643975 + 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T174615 WP_000581792.1 NZ_CP062362:2639274-2639483 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T174615 NZ_CP081257:2896146-2896466 [Phaeobacter inhibens]
ATGCGGACGTCTGAGCCGCTGGAACTCACTCTTAGCCTCAAAGCCCAAAGCGATCTTGAAGAGATTTGGCTTTACAGCGC
CCAGGTGTGGGGGCGCGATCAGGCGGACCTCTATCTGAACACGCTGCAGTCGGTCTTCGAGACGTTGTGCGATCTTCCTG
AACTGGCGCGGGAATATGAGGAGCTGTCACCAGCAGTGCGCATGCACCAGACAGGGCAGCATGTTGTGATCTACCGGGTG
CAGGGCAGCCAACTGCAGATCATCCGTGTCCTCGGTGCACGGCAAAACTGGCGGGCCGTTCTGGCCGCACTGGATGCCTG
A

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT174615 WP_000138932.1 NZ_CP062362:2638969-2639262 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT174615 NZ_CP081257:2895914-2896159 [Phaeobacter inhibens]
ATGGAAACGATTGACATTGCTCTGCCCGACCCGATGAAGGCTTGGGTGGAGACACAGACAGAAGAAGGCCGCTATTCAGA
CACCAGCGACTATGTTCAGCACCTGATCCGCAGGGATCAGACCAGACAGCAGGCTCTGAACATTTTGCAGACCGCAGTCA
CAGAAGGCATTGAGAGCGGCTTGGACGGGCCCTTCGATATGGAGACATTTAAAGCCCGTTTGCACAAAACCCATGCGGAC
GTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References